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Bioactivation of 5-Hydroxymethyl-2-Furaldehyde to an Electrophilic and Mutagenic Allylic Sulfuric Acid Ester
DC Field | Value | Language |
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dc.contributor.author | Lee, Young-Choon | - |
dc.contributor.author | Shlyankevich, Mark | - |
dc.contributor.author | Jeong, Hee-Kyung | - |
dc.contributor.author | Douglas, James S. | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:25:48Z | - |
dc.date.available | 2021-01-31T09:25:48Z | - |
dc.date.created | 2019-10-21 | - |
dc.date.issued | 1995-04 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, Vol.209 No.3, pp.996-1002 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 85292 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172668 | - |
dc.description.abstract | 5-Hydroxymethyl-2-furaldehyde (HMF), a ubiquitous food contaminant, has been proposed to be metabolically activated through sulfonation of its allylic hydroxyl functional group. In support of this idea, we have found the strong direct mutagenicity of chemically synthesized sulfuric acid ester, 5-sulfooxymethylfurfural (SMF), in Salmonella typhimurium TA104. The intrinsic mutagenicity of this reactive ester was significantly inhibited by glutathione and glutathione S-transferase activity in dialyzed rat liver cytosol. The metabolic formation of SMF was elucidated by enhanced mutagenicity of HMF in the presence of rat hepatic cytosol enriched with the sulfogroup donor, 3'-phosphoadenosine-5'-phosphosulfate (PAPS). The PAPS- and cytosol-dependent mutagenicity of HMF was markedly lessened by sulfotransferase inhibitors such as 2,6-dichloro-4-nitrophenol and dehydroepiandrosterone. These results suggest that HMF can be metabolically activated to an allylic sulfuric acid ester which may play a role as an ultimate electrophilic metabolite in toxification of the parent compound in vivo. (C) 1995 Academic Press, Inc. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Bioactivation of 5-Hydroxymethyl-2-Furaldehyde to an Electrophilic and Mutagenic Allylic Sulfuric Acid Ester | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1006/bbrc.1995.1596 | - |
dc.citation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.wosid | A1995QV60200029 | - |
dc.identifier.scopusid | 2-s2.0-0029049978 | - |
dc.citation.endpage | 1002 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 996 | - |
dc.citation.volume | 209 | - |
dc.identifier.sci | A1995QV60200029 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ARYL SULFOTRANSFERASE | - |
dc.subject.keywordPlus | DNA | - |
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