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Cancer preventive phytochemicals as speed breakers in inflammatory signaling involved in aberrant COX-2 expression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.date.accessioned | 2021-01-31T09:26:53Z | - |
dc.date.available | 2021-01-31T09:26:53Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2007-08 | - |
dc.identifier.citation | Current Cancer Drug Targets, Vol.7 No.5, pp.447-458 | - |
dc.identifier.issn | 1568-0096 | - |
dc.identifier.other | 3405 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172684 | - |
dc.description.abstract | A causal association between inflammation and cancer has long been suspected. Multiple lines of compelling evidence from clinical, epiderniologic and laboratory studies support that inflammation plays a critical role in the promotion and progression stages of carcinogenesis. Recent progress in our understanding of the molecular biology of cancer highlights the intracellular signal transduction network, including-that involved in mediating the inflammatory response, which often functions abnormally during carcinogenesis. One of the key players in inflammatory signaling is cyclooxygenase-2 (COX-2). Aberrant upregulation of COX-2 is frequently observed in various precancerous and malignant tissues. Pro-inflammatory stimuli trigger the activation of an intracellular signal transduction network comprising proline-directed serine/threonine kinases, and their downstream transcription factors, resulting in an inappropriate induction of COX-2. Therefore, the normalization of inappropriately overamplified signaling cascades implicated in chronic inflammation-associated carcinogenesis by use of COX-2 specific inhibitors has been recognized as a rational and pragmatic strategy in molecular target-based cancer prevention. This review highlights the cancer preventive effects of some anti- in flammato ry phytochemicals derived from edible plants, and their underlying molecular mechanisms with a focus on representative transcription factors and upstream kinases responsible for COX-2 induction. | - |
dc.language | 영어 | - |
dc.publisher | Bentham Science Publishers | - |
dc.title | Cancer preventive phytochemicals as speed breakers in inflammatory signaling involved in aberrant COX-2 expression | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.2174/156800907781386551 | - |
dc.citation.journaltitle | Current Cancer Drug Targets | - |
dc.identifier.wosid | 000249233700006 | - |
dc.identifier.scopusid | 2-s2.0-34547575165 | - |
dc.citation.endpage | 458 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 447 | - |
dc.citation.volume | 7 | - |
dc.identifier.sci | 000249233700006 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | INHIBITS PHORBOL ESTER | - |
dc.subject.keywordPlus | P38 MAP KINASE | - |
dc.subject.keywordPlus | INDUCED CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordPlus | CCAAT/ENHANCER-BINDING-PROTEIN | - |
dc.subject.keywordPlus | MAMMARY EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE-2 | - |
dc.subject.keywordPlus | POTENTIAL MOLECULAR TARGETS | - |
dc.subject.keywordAuthor | cancer prevention | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | NF-kappaB | - |
dc.subject.keywordAuthor | phytochemicals | - |
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