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Synthesis and properties of vinyl carbamate epoxide, a possible ultimate electrophilic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Kwang-Kyun | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Stewart, Bradley C. | - |
dc.contributor.author | Miller, James A. | - |
dc.date.accessioned | 2021-01-31T09:27:01Z | - |
dc.date.available | 2021-01-31T09:27:01Z | - |
dc.date.created | 2019-10-18 | - |
dc.date.issued | 1990-06 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, Vol.169 No.3, pp.1094-1098 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 85287 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172686 | - |
dc.description.abstract | Vinyl carbamate reacted with dimethyldioxirane in dry acetone to give a high yield of pure crystalline vinyl carbamate epoxide. This epoxide was characterized by its NMR and MS spectra and elementary analysis. It is unstable at room temperature and has a half-life in water solution of approximately 32 minutes. It reacts with adenosine to form 1,N6-ethenoadenosine and more of this etheno nucleoside was found in hydrolysates of hepatic RNA of male mice injected i.p. with the epoxide than with vinyl carbamate. Tests with Salmonella typhimurium TA1535 showed that this epoxide is a strong direct mutagen. It is also more toxic in the mouse than vinyl carbamate. Studies on the carcinogenicity of this epoxide are in progress. © 1990. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Synthesis and properties of vinyl carbamate epoxide, a possible ultimate electrophilic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/0006-291X(90)92007-M | - |
dc.citation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.wosid | A1990DL73900041 | - |
dc.identifier.scopusid | 2-s2.0-0025340017 | - |
dc.citation.endpage | 1098 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 1094 | - |
dc.citation.volume | 169 | - |
dc.identifier.sci | A1990DL73900041 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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