Publications
Detailed Information
Upregulation of VEGF by 15-deoxy-Δ12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells : Upiregulation of VEGF by 15-deoxy-delta(12,14)-prostaglandin J(2) via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Eun-Hee | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:14:52Z | - |
dc.date.available | 2021-01-31T10:14:52Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2006-12 | - |
dc.identifier.citation | Annals of the New York Academy of Sciences, Vol.1090, pp.375-384 | - |
dc.identifier.issn | 0077-8923 | - |
dc.identifier.other | 3841 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172756 | - |
dc.description.abstract | The vascular endothelial growth factor (VEGF) induces angiogenesis in ischemic or inflamed tissues during tumor growth. 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), an endogenous ligand of peroxisome proliferator-activated receptor (PPAR) gamma, has been reported to upregulate VEGF synthesis through the induction of heme oxygenase (HO)-1. In this work, we found that treatment of human breast cancer (MCF-7) cells with 15d-PGJ(2) led to time-dependent increases in the expression of HO-1. The PPAR gamma antagonist GW9662 and N-acetylcysteine failed to block induction of HO-1 by 15d-PGJ2. Elevated expression or activity of HO-1 has been reported to stimulate proliferation and to accelerate angiogenesis in several tumor cells. The induction of HO-1 expression preceded the upregulation of VEGF in MCF-7 cells stimulated with 15d-PGJ2. In another experiment, 15d-PGJ2 induced phosphorylation of extracellular signal-regulated kinase (ERK1/2) in 12 h. Treatment of MCF-7 cells with U0126 or transient transfection with dominant negative ERK (DN-ERK) abrogated 15d-PGJ(2)-induced VEGF expression. To determine whether the induction of HO-1 is responsible for ERK1/2 activation, the HO-1 inhibitor, zinc protoporphyrin (ZnPP) was used. The phosphorylation of ERK1/2 by 15d-PGJ2 was abolished by ZnPP These results suggest that 15d-PGJ(2) upregulates VEGF expression via induction of HO-1 and ERK-1 and -2 phosphorylation, which may contribute to increased angiogenesis of the tumor cells. | - |
dc.language | 영어 | - |
dc.publisher | New York Academy of Sciences | - |
dc.title | Upregulation of VEGF by 15-deoxy-Δ12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells | - |
dc.title.alternative | Upiregulation of VEGF by 15-deoxy-delta(12,14)-prostaglandin J(2) via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1196/annals.1378.041 | - |
dc.citation.journaltitle | Annals of the New York Academy of Sciences | - |
dc.identifier.wosid | 000245737100041 | - |
dc.identifier.scopusid | 2-s2.0-34247623569 | - |
dc.citation.endpage | 384 | - |
dc.citation.startpage | 375 | - |
dc.citation.volume | 1090 | - |
dc.identifier.sci | 000245737100041 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE-CELLS | - |
dc.subject.keywordPlus | FACTOR EXPRESSION | - |
dc.subject.keywordPlus | CARBON-MONOXIDE | - |
dc.subject.keywordPlus | CANCER-PATIENTS | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | MAP KINASE | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordAuthor | 15-deoxy-Delta(12,14)-prostaglandin J(2) | - |
dc.subject.keywordAuthor | heme oxygenase-1 | - |
dc.subject.keywordAuthor | VEGF | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | MCF-7 cells | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.