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Piceatannol inhibits phorbol ester-induced expression of COX-2 and iNOS in HR-1 hairless mouse skin by blocking the activation of NF-kappa B and AP-1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, Lijia | - |
dc.contributor.author | Li, Jianchun | - |
dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:15:56Z | - |
dc.date.available | 2021-01-31T10:15:56Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.citation | Inflammation Research, Vol.63 No.12, pp.1013-1021 | - |
dc.identifier.issn | 1023-3830 | - |
dc.identifier.other | 1146 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172769 | - |
dc.description.abstract | The present study was aimed at elucidating the molecular mechanisms of anti-inflammatory activity of piceatannol (trans-3,4,3',5'-tetrahydroxystilbene) in mouse skin in vivo. Female HR-1 hairless mice were topically treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) with or without piceatannol pretreatment. Epidermal protein expression was assessed by Western blot analysis. The cyclooxygenase-2 (COX-2) expression was detected by immunohistochemistry. The DNA binding of nuclear factor-kappaB (NF-kappa B) and activator protein-1 (AP-1) was examined by the electrophoretic mobility gel shift assay. The catalytic activity of I kappa B alpha kinase-beta (IKK beta) was measured by in vitro kinase assay. Pretreatment with piceatannol attenuated TPA-induced expression of COX-2 and inducible nitric oxide synthase (iNOS) in mouse skin. Piceatannol diminished nuclear translocation and the DNA binding of NF-kappa B through the blockade of phosphorylation and subsequent degradation of I kappa B alpha. Piceatannol attenuated the catalytic activity of IKK beta and inhibited the phosphorylation of mitogen-activated protein (MAP) kinases in TPA-treated mouse skin. In addition, piceatannol decreased TPA-induced expression of c-Fos and the DNA binding of AP-1. Piceatannol inhibits TPA-induced COX-2 and iNOS expression by blocking the activation of NF-kappa B and AP-1 via suppression of the IKK beta activity and phosphorylation of MAP kinases, which provides a mechanistic basis of its anti-inflammatory effects in mouse skin. | - |
dc.language | 영어 | - |
dc.publisher | Birkhauser Verlag | - |
dc.title | Piceatannol inhibits phorbol ester-induced expression of COX-2 and iNOS in HR-1 hairless mouse skin by blocking the activation of NF-kappa B and AP-1 | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1007/s00011-014-0777-6 | - |
dc.citation.journaltitle | Inflammation Research | - |
dc.identifier.wosid | 000345071900005 | - |
dc.identifier.scopusid | 2-s2.0-84911986850 | - |
dc.citation.endpage | 1021 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | 1013 | - |
dc.citation.volume | 63 | - |
dc.identifier.sci | 000345071900005 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION PATHWAYS | - |
dc.subject.keywordPlus | P38 MAP KINASE | - |
dc.subject.keywordPlus | NUCLEAR-FACTOR | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | TUMOR PROMOTION | - |
dc.subject.keywordPlus | RESVERATROL | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | TARGETS | - |
dc.subject.keywordAuthor | Piceatannol | - |
dc.subject.keywordAuthor | Cyclooxygenase-2 | - |
dc.subject.keywordAuthor | Inducible nitric oxide synthase | - |
dc.subject.keywordAuthor | Nuclear factor-kappaB | - |
dc.subject.keywordAuthor | Activator protein-1 | - |
dc.subject.keywordAuthor | Mouse skin | - |
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