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Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger
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- Authors
- Issue Date
- 1999
- Publisher
- Begell House
- Citation
- Journal of Environmental Pathology, Toxicology and Oncology, Vol.18 No.2, pp.131-139
- Abstract
- Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been widely used as a dietary spice, as well as in traditional oriental medicine. The rhizome of ginger contains pungent vanillyl ketones, including [6]-gingerol and [6]paradol, and has been reported to possess a strong anti-inflammatory activity. These pungent substances have a vanilloid structure found in other chemopreventive phytochemicals, including curcumin. In our study, we found anti-tumor-promoting properties of [6]-gingerol and [6]-paradol. Thus, topical application of [6]-gingerol or [6]-paradol 30 min prior to 12-O- tetradecanoylphorbol-13-acetate (TPA) attenuated the skin papillomagenesis initiated by 7,12-dimethylbenz[a]anthracene in female ICR mice. These substances also significantly inhibited the tumor-promoter-stimulated inflammation, TNF-α production, and activation of epidermal ornithine decarboxylase in mice. In another study, [6]-gingerol and [6]-paradol suppressed the superoxide production stimulated by TPA in differentiated HL- 60 cells. Taken together, these findings suggest that pungent vanilloids found in ginger possess potential chemopreventive activities.
- ISSN
- 0731-8898
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