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Oligonol, a lychee fruit-derived low molecular weight polyphenol formulation, inhibits UVB-induced cyclooxygenase-2 expression, and induces NAD(P)H:quinone oxidoreductase-1 expression in hairless mouse skin
DC Field | Value | Language |
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dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Choi, Ki-Seok | - |
dc.contributor.author | Fujii, Hajime | - |
dc.contributor.author | Sun, Buxiang | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:17:21Z | - |
dc.date.available | 2021-01-31T10:17:21Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2009-01 | - |
dc.identifier.citation | Journal of Functional Foods, Vol.1 No.1, pp.98-108 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.other | 3004 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172789 | - |
dc.description.abstract | Plant polyphenols with antioxidant and anti-inflammatory properties are effective in chemoprotection and chemoprevention. Oligonol is a novel formulation enriched with low molecular weight catechin-type oligomeric polyphenols. Administration of oligonol-L and oligonol-G, derived, respectively, from lychee fruit and grape seeds, by gavage significantly attenuated UVB-induced expression of COX-2 in hairless mouse skin. Intragastric administration of oligonol-L attenuated UVB-induced phosphorylation of extracellular signal-regulated protein kinase-1/2 and p38 mitogen-activated protein kinase in UVB-irradiated mouse skin. UVB irradiation induced phosphorylation of mitogen- and stress-activated kinase-1 (Msk1), Janus-activated kinase-2 (JAK2) and signal transducer and activator of transcription-3 (STAT3) in mouse skin. Pretreatment with oligonol-L diminished UVB-induced phosphorylation of Msk1, JAK2 and STAT3 in UVB-irradiated mouse skin. Furthermore, oligonol-L significantly induced the expression of NAD(P)H:quinone oxidoreductase-1 (NQO-1) in mouse skin. In summary, oligonol-L inhibited UVB-induced expression of COX-2 and various upstream kinases, and induced the expression of NQO-1, which may account for its protective effects against photoinjury, including photoageing and photocarcinogenesis. (C) 2008 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Oligonol, a lychee fruit-derived low molecular weight polyphenol formulation, inhibits UVB-induced cyclooxygenase-2 expression, and induces NAD(P)H:quinone oxidoreductase-1 expression in hairless mouse skin | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.jff.2008.09.016 | - |
dc.citation.journaltitle | Journal of Functional Foods | - |
dc.identifier.wosid | 000284514500013 | - |
dc.identifier.scopusid | 2-s2.0-67651148007 | - |
dc.citation.endpage | 108 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 98 | - |
dc.citation.volume | 1 | - |
dc.identifier.sci | 000284514500013 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | POTENTIAL UPSTREAM TARGETS | - |
dc.subject.keywordPlus | SIGNAL-REGULATED KINASE | - |
dc.subject.keywordPlus | EPIDERMAL JB6 CELLS | - |
dc.subject.keywordPlus | P38 MAP KINASE | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | HUMAN KERATINOCYTES | - |
dc.subject.keywordPlus | COX-2 EXPRESSION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordAuthor | Oligonol | - |
dc.subject.keywordAuthor | Cyclooxygenase-2 | - |
dc.subject.keywordAuthor | Mouse skin | - |
dc.subject.keywordAuthor | Msk1 | - |
dc.subject.keywordAuthor | JAK2 | - |
dc.subject.keywordAuthor | STAT3 | - |
dc.subject.keywordAuthor | NAD(P)H:quinine oxidoreductase-1 | - |
dc.subject.keywordAuthor | Photoprotection | - |
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