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15-Deoxy-Δ 12,14 -prostaglandin J 2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS : 15-Deoxy-delta(12,14)-prostaglandin J(2) induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS
DC Field | Value | Language |
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dc.contributor.author | Kim, Eun-Hee | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Kim, Do-Hee | - |
dc.contributor.author | Park, Sin-Aye | - |
dc.contributor.author | Kim, Ha-Na | - |
dc.contributor.author | Song, Na-Young | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:17:34Z | - |
dc.date.available | 2021-01-31T10:17:34Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2008-04 | - |
dc.identifier.citation | Carcinogenesis, Vol.29 No.4, pp.688-695 | - |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.other | 3211 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172793 | - |
dc.description.abstract | Recent studies suggest that inflammation is causally linked to carcinogenesis. Cyclooxygenase-2 (COX-2), a rate-limiting enzyme in the biosynthesis of prostaglandins, is inappropriately expressed in various cancers and hence recognized as one of the hallmarks of chronic inflammation-associated malignancies. However, the mechanistic role of COX-2 as a link between inflammation and cancer remains undefined. Here, we report that 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), one of the final products of COX-mediated arachidonic acid metabolism, upregulates the expression of COX-2 in the human breast cancer MCF-7 cell line. 15d-PGJ(2)-induced COX-2 expression was mediated by activation of Akt and subsequently activator protein-1 (AP-1). Furthermore, 15d-PGJ(2) formed reactive oxygen species, which led to increased phosphorylation of Akt, DNA binding of AP-1 and expression of COX-2. In contrast to 15d-PGJ(2), 9,10-dihydro-15d-PGJ(2) did not elicit any of effects induced by 15d-PGJ(2) in this study, suggesting that an electrophilic carbon center present in 15d-PGJ(2) is critical for COX-2 expression as well activation of upstream signal transduction induced by this cyclopentenone prostaglandin. Taken together, these observations suggest that 15d-PGJ(2) produced by COX-2 overexpression may function as a positive regulator of COX-2 in human breast cancer MCF-7 cells. | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press | - |
dc.title | 15-Deoxy-Δ 12,14 -prostaglandin J 2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS | - |
dc.title.alternative | 15-Deoxy-delta(12,14)-prostaglandin J(2) induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1093/carcin/bgm299 | - |
dc.citation.journaltitle | Carcinogenesis | - |
dc.identifier.wosid | 000254683800003 | - |
dc.identifier.scopusid | 2-s2.0-41849150053 | - |
dc.citation.endpage | 695 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 688 | - |
dc.citation.volume | 29 | - |
dc.identifier.sci | 000254683800003 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | VASCULAR ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | PHORBOL ESTER | - |
dc.subject.keywordPlus | CYCLOPENTENONE PROSTAGLANDINS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | C-JUN | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | INDUCTION | - |
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