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Inhibition of covalent DNA binding and mutagenicity of benzo[a]pyrene by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl) carbamoyl]acetate (YH439), a novel hepatoprotective agent
DC Field | Value | Language |
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dc.contributor.author | Surh, Y.-J. | - |
dc.contributor.author | Shlyankevich, M. | - |
dc.contributor.author | Lee, J.W. | - |
dc.contributor.author | Yoo, J.-K. | - |
dc.date.accessioned | 2021-01-31T10:21:42Z | - |
dc.date.available | 2021-01-31T10:21:42Z | - |
dc.date.created | 2019-10-21 | - |
dc.date.issued | 1996-04 | - |
dc.identifier.citation | Mutation Research - Genetic Toxicology, Vol.367 No.4, pp.219-224 | - |
dc.identifier.issn | 0165-1218 | - |
dc.identifier.other | 85301 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172861 | - |
dc.description.abstract | Isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methyl-2-thiazol-2-yl)carbamoyl]acetate (YH439) was synthesized as a hepatoprotective drug for the treatment of chronic hepatitis and liver cirrhosis. In the present investigation, we have tested YH439 for its chemoprotective activity against the carcinogen benzo[n]pyrene. The drug exhibited dose-dependent protection against bacterial mutagenesis induced by benzo[n]pyrene and its covalent binding to DNA in vitro mediated by rat hepatic postmitochondrial supernatant enriched with NADPH. The direct mutagenicity of benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide, the ultimate electrophilic and carcinogenic metabolite of benzo[a]pyrene, was also ameliorated by YH439 in a dose-dependent manner. The results of this study suggest that YH439 has a potential as a chemopreventive agent. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Inhibition of covalent DNA binding and mutagenicity of benzo[a]pyrene by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl) carbamoyl]acetate (YH439), a novel hepatoprotective agent | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/S0165-1218(96)90080-4 | - |
dc.citation.journaltitle | Mutation Research - Genetic Toxicology | - |
dc.identifier.wosid | A1996UG79800006 | - |
dc.identifier.scopusid | 2-s2.0-0029865776 | - |
dc.citation.endpage | 224 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 219 | - |
dc.citation.volume | 367 | - |
dc.identifier.sci | A1996UG79800006 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Y.-J. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | POLYCYCLIC AROMATIC-HYDROCARBONS | - |
dc.subject.keywordPlus | REGION DIOL EPOXIDES | - |
dc.subject.keywordPlus | DIALLYL SULFIDE | - |
dc.subject.keywordPlus | 5-(2-PYRAZINYL)-4-METHYL-1,2-DITHIOL-3-THIONE OLTIPRAZ | - |
dc.subject.keywordPlus | ELLAGIC ACID | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | ENZYMES | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordAuthor | chemoprevention | - |
dc.subject.keywordAuthor | chemical carcinogenesis | - |
dc.subject.keywordAuthor | antimutagenicity | - |
dc.subject.keywordAuthor | malotilate | - |
dc.subject.keywordAuthor | benzo[a]pyrene | - |
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