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Effects of selected ginsenosides on phorbol ester-induced expression of cyclooxygenase-2 and activation of NF-κB and ERK1/2 in mouse skin : Effects of selected ginsenosides on phorbol ester-induced expression of cyclooxygenase-2 and activation of NF-kappa B and ERK1/2 in mouse skin
Cited 46 time in
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Cited 56 time in Scopus
- Authors
- Issue Date
- 2002-11
- Publisher
- New York Academy of Sciences
- Citation
- Annals of the New York Academy of Sciences, Vol.973, pp.396-401
- Abstract
- Our previous studies have demonstrated that the methanol extract of heat-processed Panax ginseng C.A. Meyer exerts antioxidative, antiinflammatory, and anti-tumor-promoting effects. In the present study, we examined the antiinflammatory effects of several ginsenosides (Rb-1, Rc, Re, Rg(1), Rg(3)) derived from P ginseng. Topical application of each of these ginsenosides significantly attenuated ear edema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). These ginsenosides also suppressed expression of cyclooxygenase-2 (COX-2) and activation of NF-kappaB in the TPA-treated dorsal skin of mice. Of the ginsenosides tested, Rg(3) Was found to be most effective in terms of inhibiting TPA-induced ear edema, COX-2 expression, and NF-kappaB activation.
- ISSN
- 0077-8923
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