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Inhibition by chlorophyllin of forward and reverse bacterial mutagenicity of benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide
DC Field | Value | Language |
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dc.contributor.author | Surh, Young‐Joon | - |
dc.date.accessioned | 2021-01-31T10:23:33Z | - |
dc.date.available | 2021-01-31T10:23:33Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 1998-12 | - |
dc.identifier.citation | Phytotherapy Research, Vol.12 No.8, pp.580-583 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.other | 5216 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172889 | - |
dc.description.abstract | Chlorophyllin (CHL), a water soluble derivative of the green pigment chlorophyll, was evaluated for its antimutagenic activity towards benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE). CHL suppressed dose-dependently the formation of 8-azaguanine-resistant mutant colonies in Salmonella typhimarium TM677 treated with BPDE, Under the same experimental conditions, the cytotoxicity of this direct-acting mutagen was concomitantly blunted by CHL. The protective effect of CHL against BPDE mutagenicity was confirmed in the Salmonella histidine(+) reversion assay CHL also reduced the in vitro covalent binding of BPDE to DNA. (C) 1998 John Wiley & Sons, Ltd. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Inhibition by chlorophyllin of forward and reverse bacterial mutagenicity of benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1002/(SICI)1099-1573(199812)12:8<580::AID-PTR364>3.0.CO;2-F | - |
dc.citation.journaltitle | Phytotherapy Research | - |
dc.identifier.wosid | 000078125600010 | - |
dc.identifier.scopusid | 2-s2.0-0032442102 | - |
dc.citation.endpage | 583 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 580 | - |
dc.citation.volume | 12 | - |
dc.identifier.sci | 000078125600010 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young‐Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | COMPLEX-FORMATION | - |
dc.subject.keywordPlus | F344 RATS | - |
dc.subject.keywordPlus | BENZO< | - |
dc.subject.keywordPlus | A> | - |
dc.subject.keywordPlus | PYRENE | - |
dc.subject.keywordPlus | 6-SULFOOXYMETHYLBENZO< | - |
dc.subject.keywordPlus | A> | - |
dc.subject.keywordPlus | PYRENE | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordPlus | MICRONUCLEI | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordAuthor | chlorophyllin | - |
dc.subject.keywordAuthor | antimutagenesis | - |
dc.subject.keywordAuthor | benzo[a]pyrene-diolepoxide | - |
dc.subject.keywordAuthor | chemoprevention | - |
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