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Induction of granulocytic differentiation in acute promyelocytic leukemia cells (HL-60) by 2-(allylthio) pyrazine
DC Field | Value | Language |
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dc.contributor.author | Kong, Gu | - |
dc.contributor.author | Lee, Su Jeen | - |
dc.contributor.author | Kim, Hyun Jun | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Kim, Nak Doo | - |
dc.date.accessioned | 2021-01-31T10:24:23Z | - |
dc.date.available | 2021-01-31T10:24:23Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 1999-09 | - |
dc.identifier.citation | Cancer Letters, Vol.144 No.1, pp.1-8 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.other | 5098 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172903 | - |
dc.description.abstract | Induction of hematopoietic differentiation in human promyelocytic leukemia cells (HL-60) by new synthetic drugs or natural products has recently been recognized as a new strategy in the identification and testing of potential cancer chemopreventive and/or chemotherapeutic agents. 2-(Allythio) pyrazine (2-AP) is a pyrazine derivative of allysulfide, which has been suggested to be a potential cancer chemopreventive agent in previous in vivo and in vitro experiments. In the present study, we have investigated the inducing effect of granulocytic differentiation in HL-60 cells by 2-AP. Treatment of HL-60 cells with various concentrations of 2-AP (1-100 mu M) for 7 days showed the induction of granulocytic differentiation following both morphological examination and NET (nitroblue tetrazolium) testing (up to 40 and 52%, respectively), The expressions of bcl-2 and c myc were down-regulated during granulocytic differentiation of HL-60 cells (up to 40%). The immunoblots for G1 cyclins in the G1-S phase transition (cyclin D1 and E) showed a progressive decrease of their expressions in both concentration- and time-dependent manners (up to 30 and 50%, respectively). These results suggest that 2-AP could induce the differentiation of HL-60 cells and might have potent cancer chemoprevention and/or chemotherapy roles in human leukemias. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Induction of granulocytic differentiation in acute promyelocytic leukemia cells (HL-60) by 2-(allylthio) pyrazine | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/S0304-3835(99)00115-9 | - |
dc.citation.journaltitle | Cancer Letters | - |
dc.identifier.wosid | 000082487200001 | - |
dc.identifier.scopusid | 2-s2.0-0345493892 | - |
dc.citation.endpage | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 1 | - |
dc.citation.volume | 144 | - |
dc.identifier.sci | 000082487200001 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.contributor.affiliatedAuthor | Kim, Nak Doo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | RETINOBLASTOMA GENE-PRODUCT | - |
dc.subject.keywordPlus | RETINOIC ACID | - |
dc.subject.keywordPlus | ORGANOSULFUR COMPOUNDS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CYCLE | - |
dc.subject.keywordPlus | BCL-2 | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | CHEMOPREVENTION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordAuthor | differentiation induction | - |
dc.subject.keywordAuthor | 2-(allythio)pyrazine | - |
dc.subject.keywordAuthor | chemoprevention and chemotherapy | - |
dc.subject.keywordAuthor | human promyelocytic leukemia (HL-60) cells | - |
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