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H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-κB: An implication for invasive phenotype in rat liver epithelial cells : H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-kappa B: An implication for invasive phenotype in rat liver epithelial cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Ki Won | - |
dc.contributor.author | Kim, Mi-Sung | - |
dc.contributor.author | Kang, Nam Joo | - |
dc.contributor.author | Kim, Do-Hee | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Lee, Hyong Joo | - |
dc.contributor.author | Moon, Aree | - |
dc.date.accessioned | 2021-01-31T10:26:08Z | - |
dc.date.available | 2021-01-31T10:26:08Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2006-10 | - |
dc.identifier.citation | International Journal of Cancer, Vol.119 No.8, pp.1767-1775 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.other | 3627 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172927 | - |
dc.description.abstract | One of the most frequent events in carcinogenesis is uncontrolled activation of Ras signaling pathway. A previous study demonstrated that the introduction of H-Ras into the normal WB-F344 rat liver epithelial (WB) cell line and adult male F344 rats resulted in tumorigenicity. The present study investigated whether H-Ras induced the invasive and migrative phenotypes in WB cells, and subsequently aimed at characterizing the underlying mechanisms. H-Ras induced the invasive and migrative phenotypes of WB cells with a selective up-regulation of matrix metalloproteinase (MMP)-9, but not MMP-2. Cyclooxygenase (COX)-2 and the subsequent production of prostaglandin E-2 (PGE(2)) were also induced by H-Ras. Treatment of H-Ras WB cells with GM6001 and NS398, the inhibitors of MMPs and COX-2, respectively, significantly inhibited the H-Ras-induced invasive and migrative phenotypes. DNA binding activity of nuclear factor (NF)-kappa B, but not that of activator protein (AP)-1, was increased by H-Ras. Caffeic acid phenethyl ester and Bay 11-7082, specific inhibitors of NF-kappa B and IKK, respectively, significantly inhibited the expression of MMP-9 and COX-2, invasion and migration of H-Ras WB cells, revealing NF-kappa B as a transcriptional factor responsible for HRas-induced malignant phenotypic conversion of WB cells. Activation of ERKs pathway was critical for H-Ras-induced invasive and migrative phenotypes, up-regulation of MMP-9 and COX-2 as well as enhanced DNA binding activity of NF-kappa B in WB cells. Taken together, these results demonstrate that H-Ras up-regulates MMP-9 and COX-2 through activation of ERKs and IKK-I kappa B alpha-NF-kappa B signal pathway which may contribute to the malignant progression of WB rat liver epithelial cells. (c) 2006 Wiley-Liss, Inc. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-κB: An implication for invasive phenotype in rat liver epithelial cells | - |
dc.title.alternative | H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-kappa B: An implication for invasive phenotype in rat liver epithelial cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1002/ijc.22056 | - |
dc.citation.journaltitle | International Journal of Cancer | - |
dc.identifier.wosid | 000240514100003 | - |
dc.identifier.scopusid | 2-s2.0-33748489508 | - |
dc.citation.endpage | 1775 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 1767 | - |
dc.citation.volume | 119 | - |
dc.identifier.sci | 000240514100003 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Ki Won | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.contributor.affiliatedAuthor | Lee, Hyong Joo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACID PHENETHYL ESTER | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordPlus | INTERCELLULAR COMMUNICATION | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | IV COLLAGENASE | - |
dc.subject.keywordPlus | ALPHA KINASE | - |
dc.subject.keywordPlus | CYCLIN D1 | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | H-Ras | - |
dc.subject.keywordAuthor | MMP-9 | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordAuthor | rat liver epithelial cells | - |
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