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Ginsenoside Rg3 Inhibits Constitutive Activation of NF-κB Signaling in Human Breast Cancer (MDA-MB-231) Cells: ERK and Akt as Potential Upstream Targets
DC Field | Value | Language |
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dc.contributor.author | 김보민 | - |
dc.contributor.author | 김도희 | - |
dc.contributor.author | 박정일 | - |
dc.contributor.author | 서영준 | - |
dc.contributor.author | 나혜경 | - |
dc.date.accessioned | 2021-01-31T10:26:21Z | - |
dc.date.available | 2021-01-31T10:26:21Z | - |
dc.date.created | 2017-11-01 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.citation | 대한암예방학회지, Vol.19 No.1, pp.23-30 | - |
dc.identifier.issn | 2288-3649 | - |
dc.identifier.other | 185 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172931 | - |
dc.description.abstract | Ginsenoside Rg3, one of the major ingredients of heat-processed ginseng, has been reported to inhibit the growth of various cancer cells. We previously reported that Rg3 inhibited the proliferation and induced apoptosis of breast cancer (MDA-MB-231) cells. In the present study, we have explored the mechanism underlying the anti-proliferative and proapoptotic effects of Rg3 in MDA-MB-231 cells, which have constitutively activated NF-κB and the mutant form of p53. Rg3 inhibited DNA binding and transcriptional activity of NF-κB and these effects were attributable to its suppression of IKKβ activity, degradation of IκBα and subsequent nuclear translocation of the p65 subunit of NF-κB. Similarly, the constitutive activation of ERK and Akt through phosphorylation was gradually reduced in MDA-MB-231 cells treated with Rg3. The pharmacological inhibitors of these kinases both U0126 (MEK1/2 inhibitor) and LY294002 (PI3K inhibitor) abrogated the NF-κB DNA binding activity in MDA-MB-231 cells. In addition, Rg3 treatment lowered the levels of the mutant p53 in concentration- and time-dependent manners. Rg3 also increased the association between p53 and its negative regulator Mdm2 in MDA-MB-231 cells. These findings suggest that Rg3 induced apoptosis in MDA-MB-231 cells, which is mediated by blocking NF-κB signaling via inactivation of ERK and Akt as well as destabilization of mutant p53. | - |
dc.language | 영어 | - |
dc.publisher | 대한암예방학회 | - |
dc.title | Ginsenoside Rg3 Inhibits Constitutive Activation of NF-κB Signaling in Human Breast Cancer (MDA-MB-231) Cells: ERK and Akt as Potential Upstream Targets | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.citation.journaltitle | 대한암예방학회지 | - |
dc.citation.endpage | 30 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 23 | - |
dc.citation.volume | 19 | - |
dc.identifier.kciid | ART001865609 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | 박정일 | - |
dc.contributor.affiliatedAuthor | 서영준 | - |
dc.description.journalClass | 2 | - |
dc.subject.keywordAuthor | Ginsenoside Rg3 | - |
dc.subject.keywordAuthor | NF-κB | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | Apoptosi | - |
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