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Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yun, Jeanho | - |
dc.contributor.author | Chae, Hee-Don | - |
dc.contributor.author | Choi, Tae-Saeng | - |
dc.contributor.author | Kim, Eun-Hee | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Chung, JongkyeongK | - |
dc.contributor.author | Choi, Kyeong-Sook | - |
dc.contributor.author | Mantovani, Roberto | - |
dc.contributor.author | Shin, Deug Y. | - |
dc.date.accessioned | 2021-01-31T11:03:17Z | - |
dc.date.available | 2021-01-31T11:03:17Z | - |
dc.date.created | 2020-12-23 | - |
dc.date.issued | 2003-09 | - |
dc.identifier.citation | Journal of Biological Chemistry, Vol.278 No.38, pp.36966-36972 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.other | 119609 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172990 | - |
dc.description.abstract | Recent studies have suggested that the NF-Y transcription factor is involved in transcription repression of the cell cycle regulatory genes in a response to p53 induction or DNA damage. Here we demonstrate the cdk2-dependent phosphorylation of NF-Y and its involvement in transcription repression by the p53-p21 signaling pathway. Cdk2 phosphorylates two serine residues near the DNA-binding domain of the YA subunit of NF-Y. Cyclin A-cdk2 appears to associate with NF-Y both in vitro and in vivo. Furthermore, YA protein is phosphorylated in parallel with a cell cycle-dependent activation of cdk2 kinase and cyclin A expression. YA phosphorylation is unnecessary for heterotrimer formation with the YB-YC dimer. However, NF-Y containing a phosphorylation-deficient mutant form of YA, YA-aa, has its DNA binding activity impaired. Consistently, YA-aa inhibits transcription activation of a NF-Y target promoter, cdc2, by cdk2. These results facilitate the elucidation of the regulatory mechanisms of cell cycle progression involving the p21-cdk2-NF-Y signaling pathway. | - |
dc.language | 영어 | - |
dc.publisher | American Society for Biochemistry and Molecular Biology Inc. | - |
dc.title | Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1074/jbc.M305178200 | - |
dc.citation.journaltitle | Journal of Biological Chemistry | - |
dc.identifier.wosid | 000185318300131 | - |
dc.identifier.scopusid | 2-s2.0-0141591674 | - |
dc.citation.endpage | 36972 | - |
dc.citation.number | 38 | - |
dc.citation.startpage | 36966 | - |
dc.citation.volume | 278 | - |
dc.identifier.sci | 000185318300131 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CYCLIN-DEPENDENT KINASES | - |
dc.subject.keywordPlus | CCAAT-BINDING PROTEIN | - |
dc.subject.keywordPlus | CELL-CYCLE | - |
dc.subject.keywordPlus | MACROPHAGE DIFFERENTIATION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | CDC2 | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | REPRESSION | - |
dc.subject.keywordPlus | GENE | - |
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