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Phase II study of oxaliplatin, 5-fluorouracil and leucovorin in previously platinum-treated patients with advanced gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Kim, DY | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Lee, SH | - |
dc.contributor.author | Kim, TY | - |
dc.contributor.author | Heo, DS | - |
dc.contributor.author | Bang, YJ | - |
dc.contributor.author | Kim, NK | - |
dc.date.accessioned | 2021-01-31T11:03:52Z | - |
dc.date.available | 2021-01-31T11:03:52Z | - |
dc.date.created | 2020-12-16 | - |
dc.date.issued | 2003-03 | - |
dc.identifier.citation | Annals of Oncology, Vol.14 No.3, pp.383-387 | - |
dc.identifier.issn | 0923-7534 | - |
dc.identifier.other | 119243 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172996 | - |
dc.description.abstract | Background: Oxaliplatin shows preclinical activity in many cancer cell lines that are resistant to cisplatin, and also has synergism with 5-fluorouracil (5-FU). We undertook this study to evaluate the efficacy and toxicities of a combined oxaliplatin, 5-FU and leucovorin (LV) continuous infusion regimen in patients with advanced gastric cancer who progressed during or after treatment with 5-FU and platinum compounds. Patients and methods: Twenty-six patients with advanced gastric cancer, whose disease progressed while receiving, or after discontinuing, chemotherapy with a 5-FU and platinum regimen, were enrolled in this study. Treatment comprised oxaliplatin (85 mg/m(2) on day 1) as a 2-h infusion followed by bolus 5-FU (400 mg/m(2) on day 1), and 48-h infusion of 5-FU 2.4-3.0 g/m(2) Concurrently with LV 150 mg/m(2). Cycles were repeated at 2-week intervals. Results: Of the 23 evaluable patients, there were six partial responses (response rate 26%). All responding patients were among those who entered into this trial immediately after failure of previous chemotherapy with 5-FU and cisplatin. The median time to progression was 4.3 months and the median overall survival was 7.3 months. The most common hematologic toxicity was grade 1-2 anemia in 39 cycles (39%). No grade 4 leukopenia or thrombocytopenia were observed. The most common non-hematologic toxicity was nausea/vomiting (33%). Peripheral neuropathy of grade 1 or 2 was noted (27%), but there was no grade 3 or 4 neurotoxicity. Conclusions: This phase II study of oxaliplatin, 5-FU and LV continuous infusion showed activity in previously platinum-treated patients with advanced gastric cancer, with acceptable toxicities. | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press | - |
dc.title | Phase II study of oxaliplatin, 5-fluorouracil and leucovorin in previously platinum-treated patients with advanced gastric cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1093/annonc/mdg106 | - |
dc.citation.journaltitle | Annals of Oncology | - |
dc.identifier.wosid | 000182406700007 | - |
dc.identifier.scopusid | 2-s2.0-0037352255 | - |
dc.citation.endpage | 387 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 383 | - |
dc.citation.volume | 14 | - |
dc.identifier.sci | 000182406700007 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, TY | - |
dc.contributor.affiliatedAuthor | Heo, DS | - |
dc.contributor.affiliatedAuthor | Bang, YJ | - |
dc.contributor.affiliatedAuthor | Kim, NK | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | METASTATIC COLORECTAL-CANCER | - |
dc.subject.keywordPlus | HIGH-DOSE LEUCOVORIN | - |
dc.subject.keywordPlus | FOLINIC ACID | - |
dc.subject.keywordPlus | INFUSION | - |
dc.subject.keywordPlus | REGIMEN | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordAuthor | advanced gastric cancer | - |
dc.subject.keywordAuthor | 5-fluorouracil | - |
dc.subject.keywordAuthor | leucovorin | - |
dc.subject.keywordAuthor | oxaliplatin | - |
dc.subject.keywordAuthor | phase II study | - |
dc.subject.keywordAuthor | platinum compounds | - |
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