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Transforming growth factor-β induces apoptosis in activated murine T cells through the activation of caspase 1-1ike protease : Transforming growth factor-beta induces apoptosis in activated murine T cells through the activation of caspase 1-like protease
DC Field | Value | Language |
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dc.contributor.author | Chung, Eun Joo | - |
dc.contributor.author | Choi, Sang Hoon | - |
dc.contributor.author | Shim, Yhong-Hee | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Hur, Kuy Chung | - |
dc.contributor.author | Kim, Chul Woo | - |
dc.date.accessioned | 2021-01-31T11:07:22Z | - |
dc.date.available | 2021-01-31T11:07:22Z | - |
dc.date.created | 2020-12-21 | - |
dc.date.issued | 2000-08 | - |
dc.identifier.citation | Cellular Immunology, Vol.204 No.1, pp.46-54 | - |
dc.identifier.issn | 0008-8749 | - |
dc.identifier.other | 119283 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173038 | - |
dc.description.abstract | Transforming growth factor-beta (TGF-beta) has been known as a potent immunosuppressive cytokine that can induce apoptosis in lymphoid cells. We established an IL-2-independent cell line, CTLL-2A, from murine T cell line CTLL-2. CTLL-2A expressed higher levels of CD95, CD69, and CD18 molecules than CTLL-2 did, suggesting a more activated state in CTLL-2A than in the CTLL-2 by phenotype. Exposing both CTLL-2 and CTLL-2A to TGF-beta results in differential apoptosis patterns defined by DNA fragmentation and plasma membrane alteration. Among the bcl-2 family members, bcl-2, bcl-w, and bcl-x(L) were also differently expressed in these two cell lines. In CTLL-2A, bcl-x(L) was amplified as a major anti-apoptotic molecule, and TGF-beta-induced cell death was more enhanced than in the original cell line. Caspase 1-like protease was activated by TGF-beta treatment and consequently it cleaved bcl-x(L) in CTLL-2A. TGF-beta-induced DNA fragmentation and cleavage of bcl-x(L), were inhibited by pretreatment with tetra peptide caspase 1 inhibitor, YVAD.cmk. These findings suggest that TGF-beta induces cell death in activated murine T cells through cleavage of bcl-x(L) via activated caspase 1-like protease, which may act as an important executor in that process. (C) 2000 Academic Press. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Transforming growth factor-β induces apoptosis in activated murine T cells through the activation of caspase 1-1ike protease | - |
dc.title.alternative | Transforming growth factor-beta induces apoptosis in activated murine T cells through the activation of caspase 1-like protease | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1006/cimm.2000.1694 | - |
dc.citation.journaltitle | Cellular Immunology | - |
dc.identifier.wosid | 000089803200006 | - |
dc.identifier.scopusid | 2-s2.0-0033775776 | - |
dc.citation.endpage | 54 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 46 | - |
dc.citation.volume | 204 | - |
dc.identifier.sci | 000089803200006 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Kim, Chul Woo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TUMOR-INFILTRATING LYMPHOCYTES | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | CYTOCHROME-C | - |
dc.subject.keywordPlus | BCL-2 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | LINE | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA-1 | - |
dc.subject.keywordPlus | FACTOR-BETA-1 | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordAuthor | TGF-beta | - |
dc.subject.keywordAuthor | bcl-x(L) | - |
dc.subject.keywordAuthor | murine T cell line | - |
dc.subject.keywordAuthor | apoptosis | - |
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