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Effect of lapatinib on oral digoxin absorption in patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koch, Kevin M. | - |
dc.contributor.author | Smith, Deborah A. | - |
dc.contributor.author | Botbyl, Jeff | - |
dc.contributor.author | Arya, Nikita | - |
dc.contributor.author | Briley, Linda P. | - |
dc.contributor.author | Cartee, Leanne | - |
dc.contributor.author | White, Jane Holshouser | - |
dc.contributor.author | Beyer, Jennifer | - |
dc.contributor.author | Dar, Mohammed M. | - |
dc.contributor.author | Chung, Hyun Choel | - |
dc.contributor.author | Chu, Quincy | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.date.accessioned | 2021-01-31T11:08:34Z | - |
dc.date.available | 2021-01-31T11:08:34Z | - |
dc.date.created | 2018-10-22 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | Clinical Pharmacology in Drug Development, Vol.4 No.6, pp.449-453 | - |
dc.identifier.issn | 2160-763X | - |
dc.identifier.other | 61720 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173053 | - |
dc.description.abstract | The potential for an interaction between lapatinib and absorption of the P-glycoprotein (ABCB1) substrate digoxin at a therapeutic dose in breast cancer patients was characterized. Seventeen women with HER2-positive metastatic breast cancer received a single oral 0.5-mg dose of digoxin on days 1 and 9 and oral lapatinib 1500 mg once daily on days 2 through 9. Digoxin pharmacokinetic parameters were determined on day 1 (digoxin administration alone) and on day 9 (coadministration of lapatinib and digoxin), and parameters were compared to determine the effects of lapatinib on digoxin absorption. Concomitant medications that could affect ABCB1 were accounted for. Lapatinib 1500 mg/day increased digoxin absorption approximately 80%, implicating lapatinib inhibition of intestinal ABCB1-mediated efflux. In summary, coadministration of lapatinib with narrow therapeutic index drugs that are substrates of ABCB1 should be undertaken with caution and dose adjustment should be considered. | - |
dc.language | 영어 | - |
dc.publisher | Sage Periodicals Press | - |
dc.title | Effect of lapatinib on oral digoxin absorption in patients | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1002/cpdd.189 | - |
dc.citation.journaltitle | Clinical Pharmacology in Drug Development | - |
dc.identifier.wosid | 000368922200007 | - |
dc.identifier.scopusid | 2-s2.0-84954218000 | - |
dc.citation.endpage | 453 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 449 | - |
dc.citation.volume | 4 | - |
dc.identifier.sci | 000368922200007 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | P-GLYCOPROTEIN | - |
dc.subject.keywordPlus | INTESTINAL-ABSORPTION | - |
dc.subject.keywordPlus | MEMBRANE TRANSPORTERS | - |
dc.subject.keywordPlus | DRUG-INTERACTIONS | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EXSORPTION | - |
dc.subject.keywordPlus | QUINIDINE | - |
dc.subject.keywordPlus | KIDNEY | - |
dc.subject.keywordAuthor | lapatinib | - |
dc.subject.keywordAuthor | digoxin | - |
dc.subject.keywordAuthor | drug interaction | - |
dc.subject.keywordAuthor | p-glycoprotein | - |
dc.subject.keywordAuthor | ABCB1 | - |
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