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Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis : Molecular mechanisms of inactivation of TGF-beta receptors during carcinogenesis
DC Field | Value | Language |
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dc.contributor.author | Kim, SJ | - |
dc.contributor.author | Im, YH | - |
dc.contributor.author | Markowitz, SD | - |
dc.contributor.author | Bang, YJ | - |
dc.date.accessioned | 2021-01-31T11:08:43Z | - |
dc.date.available | 2021-01-31T11:08:43Z | - |
dc.date.created | 2020-12-23 | - |
dc.date.issued | 2000-03 | - |
dc.identifier.citation | Cytokine and Growth Factor Reviews, Vol.11 No.1-2, pp.159-168 | - |
dc.identifier.issn | 1359-6101 | - |
dc.identifier.other | 119590 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173056 | - |
dc.description.abstract | Signals from the TGF-beta s are mediated by the TGF-beta receptors and their substrates, the Smad proteins. Inactivation of either of the two transmembrane serine/threonine kinases called the TGF-beta type I and type II receptors is now known to underlie a wide variety of human pathologies including, especially carcinogenesis. Numerous studies have now demonstrated that the TGF-beta receptor complex and its downstream signaling intermediates constitute a tumor suppressor pathway. We review here a specific pathway of mutational inactivation of the TGF-beta type II receptor resulting from microsatellite instability and demonstrate that, by contrast. the most common mechanism of loss of expression of the TGF-beta type II receptor involves transcriptional repression. This provides a new target for therapeutic intervention. Published by Elsevier Science Ltd. | - |
dc.language | 영어 | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis | - |
dc.title.alternative | Molecular mechanisms of inactivation of TGF-beta receptors during carcinogenesis | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1016/S1359-6101(99)00039-8 | - |
dc.citation.journaltitle | Cytokine and Growth Factor Reviews | - |
dc.identifier.wosid | 000087707200017 | - |
dc.identifier.scopusid | 2-s2.0-0034027480 | - |
dc.citation.endpage | 168 | - |
dc.citation.number | 1-2 | - |
dc.citation.startpage | 159 | - |
dc.citation.volume | 11 | - |
dc.identifier.sci | 000087707200017 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Bang, YJ | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | HUMAN GASTRIC-CANCER | - |
dc.subject.keywordPlus | NONPOLYPOSIS COLORECTAL-CANCER | - |
dc.subject.keywordPlus | II GENE MUTATION | - |
dc.subject.keywordPlus | INSTABILITY-ASSOCIATED MUTATIONS | - |
dc.subject.keywordPlus | EWINGS-SARCOMA TRANSLOCATION | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR GENE | - |
dc.subject.keywordPlus | ETS DOMAIN PROTEIN | - |
dc.subject.keywordPlus | CELL LUNG-CANCER | - |
dc.subject.keywordPlus | MICROSATELLITE INSTABILITY | - |
dc.subject.keywordAuthor | TGF-beta | - |
dc.subject.keywordAuthor | receptors | - |
dc.subject.keywordAuthor | tumor suppressor | - |
dc.subject.keywordAuthor | transcriptional regulation | - |
dc.subject.keywordAuthor | DNA methylation | - |
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