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P-cadherin expression in gastric carcinoma: its regulation mechanism and prognostic significance
DC Field | Value | Language |
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dc.contributor.author | Kim, Min A. | - |
dc.contributor.author | Jung, Eun Ji | - |
dc.contributor.author | Lee, Hye Seung | - |
dc.contributor.author | Lee, Hee Eun | - |
dc.contributor.author | Yang, Han-Kwang | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.date.accessioned | 2021-01-31T11:12:04Z | - |
dc.date.available | 2021-01-31T11:12:04Z | - |
dc.date.created | 2020-12-21 | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | Human Pathology, Vol.41 No.6, pp.877-885 | - |
dc.identifier.issn | 0046-8177 | - |
dc.identifier.other | 119324 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173103 | - |
dc.description.abstract | P-cadherin is a member of the cadherin family and is expressed in several solid tumors. This molecule was recently highlighted with the development of a new targeted compound being studied in a clinical trial on solid tumors. In the present study, we examined the protein and messenger RNA (mRNA) expression status of P-cadherin and its promoter methylation in gastric carcinoma cell lines and tissues. Of the 10 cell lines, 4 were found to express P-cadherin protein and mRNA, and the P-cadherin gene was found to be hypomethylated in its promoter region in these cell lines. Nonneoplastic gastric mucosal tissues from gastric carcinoma patients were negative for P-cadherin protein evaluated by immunohistochemistry and Western blotting and had a methylated P-cadherin promoter region. In carcinoma tissues, 70.8% (749/1058) of cases showed P-cadherin protein expression, and P-cadherin positive cases had a well or moderately differentiated histology according to the World Health Organization classification, intestinal-type histology by Lauren classification, and an earlier pT class. Furthermore, patients with P-cadherin expressing tumors had a favorable prognosis by univariate and multivariate survival analyses. In addition, P-cadherin protein expression was found to be significantly correlated with promoter hypomethylation. In summary, P-cadherin is silenced in nonneoplastic gastric mucosa, and P-cadherin expressing tumors constitute a subset of gastric carcinoma with intestinal-type histology and a favorable prognosis. In addition, our findings suggest that P-eadherin promoter methylation underlies the regulation of its expression. These findings may aid patient selection and the interpretation of P-cadherin targeted therapy and clinical trial results. (C) 2010 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | W. B. Saunders Co., Ltd. | - |
dc.title | P-cadherin expression in gastric carcinoma: its regulation mechanism and prognostic significance | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1016/j.humpath.2009.04.031 | - |
dc.citation.journaltitle | Human Pathology | - |
dc.identifier.wosid | 000277885200012 | - |
dc.identifier.scopusid | 2-s2.0-77951937849 | - |
dc.citation.endpage | 885 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 877 | - |
dc.citation.volume | 41 | - |
dc.identifier.sci | 000277885200012 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Yang, Han-Kwang | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Kim, Woo Ho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CELL-CELL-ADHESION | - |
dc.subject.keywordPlus | JUVENILE MACULAR DYSTROPHY | - |
dc.subject.keywordPlus | PROTEIN EXPRESSION | - |
dc.subject.keywordPlus | HUMAN-MELANOMA | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | SNAIL | - |
dc.subject.keywordPlus | CDH3 | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordPlus | HYPOTRICHOSIS | - |
dc.subject.keywordAuthor | P-cadherin | - |
dc.subject.keywordAuthor | Stomach neoplasm | - |
dc.subject.keywordAuthor | Methylation | - |
dc.subject.keywordAuthor | Immunohistochemistry | - |
dc.subject.keywordAuthor | Survival analysis | - |
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