Publications
Detailed Information
Synthesis and Biological Evaluation of 3-(4-Substituted-phenyl)-N-hydroxy-2-propenamides, a New Class of Histone Deacetylase Inhibitors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Dae-Kee | - |
dc.contributor.author | Lee, Ju Young | - |
dc.contributor.author | Kim, Jae-Sun | - |
dc.contributor.author | Ryu, Je-Ho | - |
dc.contributor.author | Choi, Jin-Young | - |
dc.contributor.author | Lee, Jun Won | - |
dc.contributor.author | Im, Guang-Jin | - |
dc.contributor.author | Kim, Tae-Kon | - |
dc.contributor.author | Seo, Jung Woo | - |
dc.contributor.author | Park, Hyun-Ju | - |
dc.contributor.author | Yoo, Jakyung | - |
dc.contributor.author | Park, Jung-Hyun | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.date.accessioned | 2021-01-31T11:57:25Z | - |
dc.date.available | 2021-01-31T11:57:25Z | - |
dc.date.created | 2020-12-16 | - |
dc.date.issued | 2003-12 | - |
dc.identifier.citation | Journal of Medicinal Chemistry, Vol.46 No.26, pp.5745-5751 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.other | 119240 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173160 | - |
dc.description.abstract | Inhibitors of histone deacetylases (HDACs) have been shown to induce differentiation and/or apoptosis of human tumor cells. Novel 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides have been prepared as a new class of HDAC inhibitors and evaluated for their antiproliferative activity and HDAC inhibitory activity. Incorporation of a 1,4-phenylene carboxamide linker, shown by 5, and a 4-(dimethylamino)phenyl or 4-(pyrrolidin-1-yl)phenyl group as a cap substructure generated highly potent hydroxamic acid-based HDAC inhibitors 5a and 5b. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Synthesis and Biological Evaluation of 3-(4-Substituted-phenyl)-N-hydroxy-2-propenamides, a New Class of Histone Deacetylase Inhibitors | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1021/jm030377q | - |
dc.citation.journaltitle | Journal of Medicinal Chemistry | - |
dc.identifier.wosid | 000187243700020 | - |
dc.identifier.scopusid | 2-s2.0-10744229506 | - |
dc.citation.endpage | 5751 | - |
dc.citation.number | 26 | - |
dc.citation.startpage | 5745 | - |
dc.citation.volume | 46 | - |
dc.identifier.sci | 000187243700020 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CELL-DIFFERENTIATION | - |
dc.subject.keywordPlus | COLORIMETRIC ASSAY | - |
dc.subject.keywordPlus | ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | HUMAN TUMORS | - |
dc.subject.keywordPlus | TRICHOSTATIN | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | ACETYLATION | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | LEUKEMIA | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.