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Quality of Life in the Trastuzumab for Gastric Cancer Trial
DC Field | Value | Language |
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dc.contributor.author | Satoh, Taroh | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Gotovkin, Evgeny A. | - |
dc.contributor.author | Hamamoto, Yasuo | - |
dc.contributor.author | Kang, Yoon-Koo | - |
dc.contributor.author | Moiseyenko, Vladimir M. | - |
dc.contributor.author | Ohtsu, Atsushi | - |
dc.contributor.author | Van Cutsem, Eric | - |
dc.contributor.author | Al-Sakaff, Nedal | - |
dc.contributor.author | Urspruch, Alexa | - |
dc.contributor.author | Hill, Julie | - |
dc.contributor.author | Weber, Harald A. | - |
dc.contributor.author | Chung, Hyun-Cheol | - |
dc.date.accessioned | 2021-01-31T12:01:13Z | - |
dc.date.available | 2021-01-31T12:01:13Z | - |
dc.date.created | 2020-12-17 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.citation | Oncologist, Vol.19 No.7, pp.712-719 | - |
dc.identifier.issn | 1083-7159 | - |
dc.identifier.other | 119268 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173211 | - |
dc.description.abstract | Background. The Trastuzumab for Gastric Cancer phase III trial demonstrated that combining trastuzumab with chemotherapy significantly improved overall survival compared with chemotherapy alone in HER2-positive advanced gastric or gastroesophageal junction cancer. We report health-related quality of life (HRQoL) and quality-adjusted time without symptomsofdisease or toxicity (Q-TWiST) results from this trial. Patients and Methods. Patients were randomized to receive six cycles of chemotherapy given every 3 weeks (capecitabine or fluorouracil, plus cisplatin) either alone or combined with administration of trastuzumab every 3 weeks until disease progression. At each clinical visit, HRQoL was assessed using two European Organization for Research and Treatment of Cancer quality of life questionnaires, QLQ-C30 and QLQ-STO22. Q-TWiST methodology was applied retrospectively using the clinical data and utility coefficients. Results. Trastuzumab plus chemotherapy prolonged time to 10% definitive deterioration in all QLQ-C30 and QLQ-STO22 scores, including QLQ-C30 global health status versus chemotherapy alone, from 6.4 months to 10.2 months. In addition, trastuzumab plus chemotherapy extended Q-TWiST by 2.42 months compared with chemotherapy alone. Conclusion. Compared with chemotherapy alone, trastuzumab plus chemotherapy prolongs time to deterioration of HRQoL and increases quality-adjusted survival in patients with HER2-positive gastric or gastroesophageal junction cancer. | - |
dc.language | 영어 | - |
dc.publisher | AlphaMed Press Inc | - |
dc.title | Quality of Life in the Trastuzumab for Gastric Cancer Trial | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1634/theoncologist.2014-0058 | - |
dc.citation.journaltitle | Oncologist | - |
dc.identifier.wosid | 000338190600006 | - |
dc.identifier.scopusid | 2-s2.0-84903631229 | - |
dc.citation.endpage | 719 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 712 | - |
dc.citation.volume | 19 | - |
dc.identifier.sci | 000338190600006 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | METASTATIC BREAST-CANCER | - |
dc.subject.keywordPlus | PHASE-III | - |
dc.subject.keywordPlus | ESOPHAGOGASTRIC CANCER | - |
dc.subject.keywordPlus | Q-TWIST | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | FLUOROURACIL | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | JUNCTION | - |
dc.subject.keywordAuthor | Chemotherapy | - |
dc.subject.keywordAuthor | Gastric cancer | - |
dc.subject.keywordAuthor | HER2 | - |
dc.subject.keywordAuthor | Quality of life | - |
dc.subject.keywordAuthor | Trastuzumab | - |
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