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Factors associated with neurodevelopment in preterm infants with systematic inflammation
DC Field | Value | Language |
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dc.contributor.author | Lee, Eun Sun | - |
dc.contributor.author | Kim, Ee-Kyung | - |
dc.contributor.author | Shin, Seung han | - |
dc.contributor.author | Choi, Young-Hun | - |
dc.contributor.author | Jung, Young Hwa | - |
dc.contributor.author | Kim, Sae Yun. | - |
dc.contributor.author | Koh, Ji Won | - |
dc.contributor.author | Choi, Eui Kyung | - |
dc.contributor.author | Cheon, Jung-Eun | - |
dc.contributor.author | Kim, Han-Suk | - |
dc.date.accessioned | 2021-05-18T01:17:53Z | - |
dc.date.available | 2021-05-18T10:26:11Z | - |
dc.date.issued | 2021-03-08 | - |
dc.identifier.citation | BMC Pediatrics. 2021 Mar 08;21(1):114 | ko_KR |
dc.identifier.issn | 1471-2431 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174406 | - |
dc.description.abstract | Background
Several studies have suggested that adverse neurodevelopment could be induced by systemic inflammation in preterm infants. We aimed to investigate whether preterm infants with systemic inflammation would have impaired neurodevelopment and which biomarkers and neurophysiologic studies during inflammation are associated with poor neurodevelopment. Methods This prospective cohort study enrolled infants born before 30 weeks of gestation or with birth weight < 1250 g. Infants were grouped according to the presence of systemic inflammation: Control (no inflammation, n = 49), I (systemic inflammation, n = 45). Blood and cerebrospinal fluid samples for markers of brain injury and inflammation were collected and amplitude-integrated electroencephalography (aEEG) was performed within 4 h of septic workup. We evaluated aEEG at 35 weeks postmenstrual age (PMA), head circumference at 36 weeks PMA, and brain MRI at discharge. The Bayley Scales of Infant and Toddler Development III (Bayley-III) was performed at a corrected age (CA) of 18 months. Results The I group had more white matter injuries (2 vs. 26.7%, Control vs. I, respectively) at the time of discharge, lower brain functional maturation (9.5 vs. 8), and smaller head size (z-score − 1.45 vs. -2.12) at near-term age and poorer neurodevelopment at a CA of 18 months than the control (p < 0.05). Among the I group, the proportion of immature neutrophils (I/T ratios) and IL-1 beta levels in the CSF were associated with aEEG measures at the day of symptom onset (D0). Seizure spike on aEEG at D0 was significantly correlated with motor and social-emotional domains of Bayley-III (p < 0.05). The I/T ratio and CRP and TNF-α levels of blood at D0, white matter injury on MRI at discharge, head circumference and seizure spikes on aEEG at near-term age were associated with Bayley-III scores at a CA of 18 months. Conclusions Systemic inflammation induced by clinical infection and NEC are associated with neurodevelopmental impairment in preterm infants. The seizure spike on aEEG, elevated I/T ratio, CRP, and plasma TNF-alpha during inflammatory episodes are associated with poor neurodevelopment. | ko_KR |
dc.description.sponsorship | This research was supported by the Basic Science Research Programme through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2012R1A1A2044109, 2017R1D1A1B03036383, and 2017R1D1A1B04030931) and supported by grant no 0420160450 from the SNUH Research Fund | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Premature | - |
dc.subject | White matter injury | - |
dc.subject | Sepsis | - |
dc.subject | Necrotizing enterocolitis | - |
dc.subject | Inflammation | - |
dc.subject | Amplitude integrated encephalography | - |
dc.subject | Cytokine | - |
dc.title | Factors associated with neurodevelopment in preterm infants with systematic inflammation | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이은선 | - |
dc.contributor.AlternativeAuthor | 김의경 | - |
dc.contributor.AlternativeAuthor | 신승한 | - |
dc.contributor.AlternativeAuthor | 최영훈 | - |
dc.contributor.AlternativeAuthor | 정영화 | - |
dc.contributor.AlternativeAuthor | 김새윤 | - |
dc.contributor.AlternativeAuthor | 고지원 | - |
dc.contributor.AlternativeAuthor | 최의경 | - |
dc.contributor.AlternativeAuthor | 전정은 | - |
dc.contributor.AlternativeAuthor | 김한숙 | - |
dc.identifier.doi | 10.1186/s12887-021-02583-6 | - |
dc.citation.journaltitle | BMC Pediatrics | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-03-14T04:17:53Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 114 | ko_KR |
dc.citation.volume | 21 | ko_KR |
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