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Intratracheal inoculation of human varicella zoster virus (VZV; MAV strain) vaccine successfully induced VZV IgG antibodies in rhesus monkeys
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jong-Min | - |
dc.contributor.author | Park, Chung-Gyu | - |
dc.date.accessioned | 2021-07-30T01:13:28Z | - |
dc.date.available | 2021-07-30T10:28:59Z | - |
dc.date.issued | 2021-05-22 | - |
dc.identifier.citation | Laboratory Animal Research. 2021 May 22;37(1):14 | ko_KR |
dc.identifier.issn | 2233-7660 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174772 | - |
dc.description.abstract | Background
The objective of this study was to investigate whether the use of live attenuated varicella zoster virus (VZV) MAV vaccination can efficiently induce VZV antibody production in naive rhesus monkeys as an approach to prevent simian varicella virus (SVV) reactivation in animals immunosuppressed for transplantation studies. Results Clinically available human VZV vaccine was used to induce the production of anti-VZV antibodies in rhesus monkeys. A vial of the vaccine was subcutaneously injected at 0 week, and the second and third vaccination was performed at 5 and 6 weeks by intratracheal inoculation. The titer of anti-VZV IgG was assessed at 0, 2, 4, 6, and 7 weeks. At 2 weeks, 3/16 were seropositive for VZV IgG. At 6 weeks, 9/16 were shown to be seropositive. At 7 weeks, 16/16 were found to be seropositive. Conclusions The VZV vaccine via intratrachael inoculation was shown to induce VZV IgG humoral immunity in rhesus monkeys and may be important immunosuppressed macaques for transplantation studies. Although the humoral immunity produced is an important finding, further studies will be necessary to confirm possible protection and it could protect probably against SVV infection in rhesus monkey. | ko_KR |
dc.description.sponsorship | This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health & Welfare, Republic of Korea (Project No.HI13C0954), the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (Grant No. NRF-2020R1A2C1004557 to Kim JM), and Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01345302) Rural Development Administration, Republic of Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Simian varicella virus | - |
dc.subject | Varicella-zoster virus | - |
dc.subject | Immunization | - |
dc.subject | Latent infection | - |
dc.subject | Rhesus monkey | - |
dc.title | Intratracheal inoculation of human varicella zoster virus (VZV; MAV strain) vaccine successfully induced VZV IgG antibodies in rhesus monkeys | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김종민 | - |
dc.contributor.AlternativeAuthor | 박정규 | - |
dc.identifier.doi | 10.1186/s42826-021-00091-3 | - |
dc.citation.journaltitle | Laboratory Animal Research | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-05-23T03:17:16Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 14 | ko_KR |
dc.citation.volume | 37 | ko_KR |
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