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Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yong Gyu | - |
dc.contributor.author | Bak, Myeong Seong. | - |
dc.contributor.author | Kim, Ahbin | - |
dc.contributor.author | Kim, Yujin | - |
dc.contributor.author | Chae, Yun-Cheol | - |
dc.contributor.author | Kim, Ye Lee | - |
dc.contributor.author | Chun, Yang-Sook | - |
dc.contributor.author | An, Joon-Yong | - |
dc.contributor.author | Seo, Sang-Beom | - |
dc.contributor.author | Kim, Sang Jeong | - |
dc.contributor.author | Lee, Yong-Seok | - |
dc.date.accessioned | 2021-08-19T08:21:46Z | - |
dc.date.available | 2021-08-19T17:23:08Z | - |
dc.date.issued | 2021-07-03 | - |
dc.identifier.citation | Molecular Brain. 2021 Jul 03;14(1):106 | ko_KR |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174805 | - |
dc.description.abstract | Histone modifications are a key mechanism underlying the epigenetic regulation of gene expression, which is critically involved in the consolidation of multiple forms of memory. However, the roles of histone modifications in cerebellum-dependent motor learning and memory are not well understood. To test whether changes in histone methylation are involved in cerebellar learning, we used heterozygous Kdm3b knockout (Kdm3b+/−) mice, which show reduced lysine 9 on histone 3 (H3K9) demethylase activity. H3K9 di-methylation is significantly increased selectively in the granule cell layer of the cerebellum of Kdm3b+/− mice. In the cerebellum-dependent optokinetic response (OKR) learning, Kdm3b+/− mice show deficits in memory consolidation, whereas they are normal in basal oculomotor performance and OKR acquisition. In addition, RNA-seq analyses revealed that the expression levels of several plasticity-related genes were altered in the mutant cerebellum. Our study suggests that active regulation of histone methylation is critical for the consolidation of cerebellar motor memory. | ko_KR |
dc.description.sponsorship | This work was supported by grants to S.B.S. and Y.-S.L. (NRF2019R1A4A2001609), Y.-S.L. (NRF-2017M3C7A1026959), and S.J.K. (NRF2018R1A5A2025964) from the National Research Foundation of Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Kdm3b | - |
dc.subject | Optokinetic response (OKR) | - |
dc.subject | Histone modifcation | - |
dc.subject | Cerebellum | - |
dc.title | Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김용규 | - |
dc.contributor.AlternativeAuthor | 박명성 | - |
dc.contributor.AlternativeAuthor | 김아빈 | - |
dc.contributor.AlternativeAuthor | 김유진 | - |
dc.contributor.AlternativeAuthor | 채윤철 | - |
dc.contributor.AlternativeAuthor | 김예리 | - |
dc.contributor.AlternativeAuthor | 전양숙 | - |
dc.contributor.AlternativeAuthor | 안준용 | - |
dc.contributor.AlternativeAuthor | 서상범 | - |
dc.contributor.AlternativeAuthor | 김상정 | - |
dc.contributor.AlternativeAuthor | 이용석 | - |
dc.identifier.doi | 10.1186/s13041-021-00815-5 | - |
dc.citation.journaltitle | Molecular Brain | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-07-04T03:22:07Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 106 | ko_KR |
dc.citation.volume | 14 | ko_KR |
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