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Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice
DC Field | Value | Language |
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dc.contributor.author | Han, Dae H. | - |
dc.contributor.author | Hong, Ilgang | - |
dc.contributor.author | Choi, Ja E. | - |
dc.contributor.author | Park, Pojeong | - |
dc.contributor.author | Baek, Jun-Yeong | - |
dc.contributor.author | Park, HyoJin | - |
dc.contributor.author | Ide, Soichiro | - |
dc.contributor.author | Mishina, Masayoshi | - |
dc.contributor.author | Ikeda, Kazutaka | - |
dc.contributor.author | Kaang, Bong-Kiun | - |
dc.date.accessioned | 2022-03-21T04:10:58Z | - |
dc.date.available | 2022-03-21T04:10:58Z | - |
dc.date.issued | 2021-12-07 | - |
dc.identifier.citation | Molecular Brain. 2021 Dec 07;14(1):174 | - |
dc.identifier.uri | https://doi.org/10.1186/s13041-021-00883-7 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177084 | - |
dc.description.abstract | Abstract
Ketamine, a non-competitive antagonist of the N-methyl-d-aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect. It exerts psychomimetic effects, yet demands a further investigation of its mechanism. Previous research showed that ketamine did no longer promote hyperlocomotion in GluN2D knockout (KO) mice, which is a subunit of NMDAR. In the present study, we tested whether GluN2D-containing NMDARs participate in the physiological changes in the medial prefrontal cortex (mPFC) triggered by ketamine. Sub-anesthetic dose of ketamine (25mg/kg) elevated the frequency of spontaneous excitatory postsynaptic currents (sEPSC) in wild-type (WT) mice, but not in GluN2D KO mice, 1h after the injection. The amplitude of sEPSC and paired-pulse ratio (PPR) were unaltered by ketamine in both WT and GluN2D KO mice. These findings suggest that GluN2D-containing NMDARs might play a role in the ketamine-mediated changes in glutamatergic neurons in mPFC and, presumably, in ketamine-induced hyperlocomotion. | - |
dc.title | Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-12-12T04:12:44Z | - |
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