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Prognostic significance of natural killer cell-associated markers in gastric cancer: quantitative analysis using multiplex immunohistochemistry
DC Field | Value | Language |
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dc.contributor.author | Na, Hee Y. | - |
dc.contributor.author | Park, Yujun | - |
dc.contributor.author | Nam, Soo K. | - |
dc.contributor.author | Koh, Jiwon | - |
dc.contributor.author | Kwak, Yoonjin | - |
dc.contributor.author | Ahn, Sang-Hoon | - |
dc.contributor.author | Park, Do J. | - |
dc.contributor.author | Kim, Hyung-Ho | - |
dc.contributor.author | Lee, Kyu S. | - |
dc.contributor.author | Lee, Hye S. | - |
dc.date.accessioned | 2022-03-21T04:11:08Z | - |
dc.date.available | 2022-03-21T04:11:08Z | - |
dc.date.issued | 2021-12-24 | - |
dc.identifier.citation | Journal of Translational Medicine. 2021 Dec 24;19(1):529 | - |
dc.identifier.uri | https://doi.org/10.1186/s12967-021-03203-8 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177093 | - |
dc.description.abstract | Abstract
Background Natural killer (NK) cells mediate the anti-tumoral immune response as an important component of innate immunity. The aim of this study was to investigate the prognostic significance and functional implication of NK cell-associated surface receptors in gastric cancer (GC) by using multiplex immunohistochemistry (mIHC). Methods We performed an mIHC on tissue microarray slides, including 55 GC tissue samples. A total of 11 antibodies including CD57, NKG2A, CD16, HLA-E, CD3, CD20, CD45, CD68, CK, SMA, and ki-67 were used. CD45 + CD3-CD57 + cells were considered as CD57 + NK cells. Results Among CD45 + immune cells, the proportion of CD57 + NK cell was the lowest (3.8%), whereas that of CD57 + and CD57- T cells (65.5%) was the highest, followed by macrophages (25.4%), and B cells (5.3%). CD57 + NK cells constituted 20% of CD45 + CD57 + immune cells while the remaining 80% were CD57 + T cells. The expression of HLA-E in tumor cells correlated with that in tumoral T cells, B cells, and macrophages, but not CD57 + NK cells. The higher density of tumoral CD57 + NK cells and tumoral CD57 + NKG2A + NK cells was associated with inferior survival. Conclusions Although the number of CD57 + NK cells was lower than that of other immune cells, CD57 + NK cells and CD57 + NKG2A + NK cells were significantly associated with poor outcomes, suggesting that NK cell subsets play a critical role in GC progression. NK cells and their inhibitory receptor, NKG2A, may be potential targets in GC. | - |
dc.title | Prognostic significance of natural killer cell-associated markers in gastric cancer: quantitative analysis using multiplex immunohistochemistry | - |
dc.type | Journal Article | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-12-26T04:07:23Z | - |
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