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Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population
DC Field | Value | Language |
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dc.contributor.author | Park, Han-Ki | - |
dc.contributor.author | Yoo, Seok-Ju | - |
dc.contributor.author | Kim, Taek S. | - |
dc.contributor.author | Kim, Byung-Keun | - |
dc.contributor.author | Jang, Sekyung | - |
dc.contributor.author | Kim, Sung Y. | - |
dc.contributor.author | Lee, Kwan | - |
dc.date.accessioned | 2022-03-21T04:11:19Z | - |
dc.date.available | 2022-03-21T04:11:19Z | - |
dc.date.issued | 2022-01-31 | - |
dc.identifier.citation | Allergy, Asthma & Clinical Immunology. 2022 Jan 31;18(1):6 | - |
dc.identifier.uri | https://doi.org/10.1186/s13223-022-00648-4 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177110 | - |
dc.description.abstract | Abstract
Background Staphylococcus aureus (SA) nasal carriage (SA carriage) and IgE-sensitization to SA enterotoxin (SE IgE-sensitization) are known to be associated with chronic airway disease. Objective This study aimed to evaluate the differences in risk factors, type 2 inflammation and respiratory symptoms between SA carriage and SE IgE-sensitization. Methods We conducted a cross-sectional study of a community-based adult population to evaluate the environmental exposure and health impact of the Pohang Industrial Complex, Korea. Participants were examined based on self-reported questionnaires, nasal swab, and blood sampling. Results There were 307 participants, and the overall prevalence of SA carriage and SE IgE-sensitization was 26.1% (80/307) and 25.7% (79/307), respectively. An urban environment was significantly correlated with SA carriage, whereas age and obesity were significantly correlated with SE IgE-sensitization. SA carriage was not associated with an increase in total IgE and blood eosinophil count, whereas SE IgE-sensitization was associated with an increased total IgE and blood eosinophil count. SA carriage was significantly correlated with cough persisting for more than three weeks (OR, 3.044; 95% CI, 1.137–8.153) and sputum (OR, 2.429; 95% CI, 1.008–5.854). SE IgE-sensitization was a significant correlation with only sputum (OR, 2.452; 95% CI, 1.066–5.640). SA carriage and SE IgE-sensitization showed a synergistic effect on the prevalence of cough and sputum. Conclusion SA carriage was associated with the urban environment, and SE IgE-sensitization was associated with the elderly and obesity. SA carriage and SE IgE-sensitization had different correlation with type 2 inflammation and airway symptoms. | - |
dc.title | Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population | - |
dc.type | Journal Article | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2022-02-06T04:14:58Z | - |
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