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Immune recurrence score using 7 immunoregulatory protein expressions can predict recurrence in stage I–III breast cancer patients
DC Field | Value | Language |
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dc.contributor.author | Lee, Dae-Won | - |
dc.contributor.author | Ryu, Han Suk | - |
dc.contributor.author | Jin, Min-Sun | - |
dc.contributor.author | Lee, Kyung-Hun | - |
dc.contributor.author | Suh, Koung Jin | - |
dc.contributor.author | Youk, Jeonghwan | - |
dc.contributor.author | Kim, Jung Youn | - |
dc.contributor.author | Min, Ahrum | - |
dc.contributor.author | Lee, Han-Byoel | - |
dc.contributor.author | Moon, Hyeong-Gon | - |
dc.contributor.author | Kim, Tae-Yong | - |
dc.contributor.author | Han, Sae-Won | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Park, In Ae | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.date.accessioned | 2022-03-22T09:10:25Z | - |
dc.date.available | 2022-03-22T09:10:25Z | - |
dc.date.created | 2019-09-26 | - |
dc.date.created | 2019-09-26 | - |
dc.date.created | 2019-09-26 | - |
dc.date.created | 2019-09-26 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.citation | British Journal of Cancer, Vol.121 No.3, pp.230-236 | - |
dc.identifier.issn | 0007-0920 | - |
dc.identifier.other | 84553 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177194 | - |
dc.description.abstract | BACKGROUND: Immune cells in the tumour microenvironment play an essential role in tumorigenesis. This study aimed to evaluate the immunoregulatory protein expression of breast cancer and reveal their prognostic role. METHODS: Expression of 10 immune markers (PD-1/PD-L1/PD-L2/IDO/TIM-3/OX40/OX40L/B7-H2/B7-H3/B7-H4) with known/possible clinical relevance was identified in stromal tumour-infiltrating lymphocytes or tumour tissue of stage I-III breast cancer patients. RESULTS: A total of 392 patients, including 271(69.1%) luminal A, 36(9.2%) luminal B, 32(8.2%) HER2-positive and 53(13.5%) triple negative disease, were included. Expression of PD-1 and PD-L1 was higher in HER2-positive and triple negative disease. By contrast, expression of TIM-3, OX40 and OX40L were higher in luminal disease. We devised an immune recurrence score (IRS) using seven markers with prognostic value (B7-H2/B7-H3/B7-H4/OX40/OX40L/PD-L1/PD-L2). Patients were classified as high-risk (7.9%), intermediate-risk (67.6%), or low-risk (24.5%). In the multivariate analysis, IRS low-risk (adjusted HR 0.14, p = 0.001) and intermediate-risk (adjusted HR 0.32, p = 0.002) had significantly lower risk of recurrence compared with high-risk. The prognostic role of IRS was maintained in both luminal A and non-luminal A patients. CONCLUSIONS: This study identified immunoregulatory protein expression of breast cancer patients using 10 immune markers. In addition, we devised an IRS which may predict recurrence in stage I-III breast cancer patients. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Immune recurrence score using 7 immunoregulatory protein expressions can predict recurrence in stage I–III breast cancer patients | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1038/s41416-019-0511-9 | - |
dc.citation.journaltitle | British Journal of Cancer | - |
dc.identifier.wosid | 000477837000006 | - |
dc.identifier.scopusid | 2-s2.0-85068937326 | - |
dc.citation.endpage | 236 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 230 | - |
dc.citation.volume | 121 | - |
dc.identifier.sci | 000477837000006 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Moon, Hyeong-Gon | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Han, Wonshik | - |
dc.contributor.affiliatedAuthor | Park, In Ae | - |
dc.contributor.affiliatedAuthor | Noh, Dong-Young | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TUMOR-INFILTRATING LYMPHOCYTES | - |
dc.subject.keywordPlus | B7-H3 LIGAND EXPRESSION | - |
dc.subject.keywordPlus | PEMBROLIZUMAB | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | CELL | - |
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