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Effect of Time Interval between Breast-Conserving Surgery and Radiation Therapy on Outcomes of Node-Positive Breast Cancer Patients Treated with Adjuvant Doxorubicin/Cyclophosphamide Followed by Taxane
DC Field | Value | Language |
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dc.contributor.author | Koh, Hyeon Kang | - |
dc.contributor.author | Shin, Kyung Hwan | - |
dc.contributor.author | Kim, Kyubo | - |
dc.contributor.author | Lee, Eun Sook | - |
dc.contributor.author | Park, In Hae | - |
dc.contributor.author | Lee, Keun Seok | - |
dc.contributor.author | Ro, Jungsil | - |
dc.contributor.author | Jung, So-Youn | - |
dc.contributor.author | Lee, Seeyoun | - |
dc.contributor.author | Kim, Seok Won | - |
dc.contributor.author | Kang, Han-Sung | - |
dc.contributor.author | Chie, Eui Kyu | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Lee, Kyung-Hun | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Ha, Sung Whan | - |
dc.date.accessioned | 2022-03-22T09:22:45Z | - |
dc.date.available | 2022-03-22T09:22:45Z | - |
dc.date.created | 2018-08-28 | - |
dc.date.created | 2018-08-28 | - |
dc.date.created | 2018-08-28 | - |
dc.date.created | 2018-08-28 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.citation | Cancer Research and Treatment, Vol.48 No.2, pp.483-490 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.other | 47401 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177275 | - |
dc.description.abstract | Purpose This study evaluated the effect of surgery-radiotherapy interval (SRI) on outcomes in patients treated with adjuvant radiotherapy (RT) after breast-conserving surgery (BCS) and adjuvant four cycles of doxorubicin/cyclophosphamide (AC) followed by four cycles of taxane. Materials and Methods From 1999 to 2007, 397 eligible patients were diagnosed. The effect of SRI on outcomes was analyzed using a Cox proportional hazards model, and a maximal chi-square method was used to identify optimal cut-off value of SRI for each outcome. Results The median SRI was 6.7 months (range, 5.6 to 10.3 months). A SRI of 7 months was the significant cut-off value for distant metastasis-free survival (DMFS) and disease-free survival (DFS) using a maximal chi-square method. For overall survival, a significant cut-off value was not found. The patients with SRI > 7 months had worse 6-year DMFS and DFS than those with SRI <= 7 months on univariate analysis (DMFS, 81% vs. 91%, p=0.003; DFS, 78% vs. 89%, p=0.002). On multivariate analysis, SRI > 7 months did not affect DMFS and DFS. Conclusion RT delayed for more than 7 months after BCS and adjuvant four cycles of AC followed by four cycles of taxane did not compromise clinical outcomes. | - |
dc.language | 영어 | - |
dc.publisher | 대한암학회 | - |
dc.title | Effect of Time Interval between Breast-Conserving Surgery and Radiation Therapy on Outcomes of Node-Positive Breast Cancer Patients Treated with Adjuvant Doxorubicin/Cyclophosphamide Followed by Taxane | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.4143/crt.2015.111 | - |
dc.citation.journaltitle | Cancer Research and Treatment | - |
dc.identifier.wosid | 000374197200007 | - |
dc.identifier.scopusid | 2-s2.0-84963808597 | - |
dc.citation.endpage | 490 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 483 | - |
dc.citation.volume | 48 | - |
dc.identifier.sci | 000374197200007 | - |
dc.identifier.kciid | ART002099153 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Shin, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | Chie, Eui Kyu | - |
dc.contributor.affiliatedAuthor | Han, Wonshik | - |
dc.contributor.affiliatedAuthor | Noh, Dong-Young | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Ha, Sung Whan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | DELAY | - |
dc.subject.keywordAuthor | Breast neoplasms | - |
dc.subject.keywordAuthor | Segmental mastectomy | - |
dc.subject.keywordAuthor | Time-to-treatment | - |
dc.subject.keywordAuthor | Radiotherapy | - |
dc.subject.keywordAuthor | Adjuvant chemotherapy | - |
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