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Multiparametric fully-integrated 18-FDG PET/MRI of advanced gastric cancer for prediction of chemotherapy response: a preliminary study
DC Field | Value | Language |
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dc.contributor.author | Lee, Dong Ho | - |
dc.contributor.author | Kim, Se Hyung | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Kim, Tae-Yong | - |
dc.contributor.author | Han, Joon Koo | - |
dc.date.accessioned | 2022-03-22T09:23:08Z | - |
dc.date.available | 2022-03-22T09:23:08Z | - |
dc.date.created | 2018-09-05 | - |
dc.date.created | 2018-09-05 | - |
dc.date.created | 2018-09-05 | - |
dc.date.created | 2018-09-05 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.citation | European Radiology, Vol.26 No.8, pp.2771-2778 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.other | 50669 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177282 | - |
dc.description.abstract | To investigate usefulness of multiparametric fully integrated 18-FDG PET/MRI in predicting treatment response after chemotherapy for unresectable advanced gastric cancers (AGCs). Eleven patients with unresectable AGCs underwent multiparametric 18-FDG PET/MRI examinations prior to chemotherapy. Perfusion parameters obtained via dynamic contrast-enhanced MRI, apparent diffusion coefficient values from diffusion-weighted images, and maximum standardized uptake values (SUVmax) from 18-FDG PET were measured. For parameters obtained from 18-FDG PET/MRI data, interobserver agreement was obtained using intraclass correlation coefficients (ICC) and chemotherapy response relationship was evaluated using the Mann-Whitney test and receiver operating characteristic analysis. After chemotherapy, six patients were classified into the responder group and five patients into the non-responder group. For all parameters, moderate to nearly perfect agreement was achieved (ICC = 0.452-0.911). K (trans) values (P = 0.018) and initial area under the curves (iAUCs) (P = 0.045) of gastric cancers were significantly higher in responder group than in non-responder group. The area under the curve was 0.917 for K (trans) and 0.867 for iAUC. However, SUVmax values were not significantly different between the two groups. Multiparametric approach using fully integrated 18-FDG PET/MRI was shown to be feasible for patients with unresectable gastric cancers. In addition, K (trans) and iAUC values can be used as early predictive markers for chemotherapy response. Multiparametric 18-FDG PET/MRI is feasible for patients with unresectable advanced gastric cancer K (trans) and iAUC were significantly higher in the responder group of patients K (trans) , iAUC can be utilized as early predictive markers for chemotherapeutic response. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | Multiparametric fully-integrated 18-FDG PET/MRI of advanced gastric cancer for prediction of chemotherapy response: a preliminary study | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1007/s00330-015-4105-5 | - |
dc.citation.journaltitle | European Radiology | - |
dc.identifier.wosid | 000379192500040 | - |
dc.identifier.scopusid | 2-s2.0-84948696952 | - |
dc.citation.endpage | 2778 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 2771 | - |
dc.citation.volume | 26 | - |
dc.identifier.sci | 000379192500040 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Han, Joon Koo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CONTRAST-ENHANCED MRI | - |
dc.subject.keywordPlus | THERAPEUTIC RESPONSE | - |
dc.subject.keywordPlus | ONCOLOGIC PET/MRI | - |
dc.subject.keywordPlus | PARAMETERS | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | ABDOMEN | - |
dc.subject.keywordPlus | TRACER | - |
dc.subject.keywordPlus | PET/CT | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordAuthor | Multiparametric 18F-fluorodexoyglucose PET/MRI | - |
dc.subject.keywordAuthor | Dynamic contrast-enhanced MRI | - |
dc.subject.keywordAuthor | Advanced gastric cancer | - |
dc.subject.keywordAuthor | Palliative chemotherapy | - |
dc.subject.keywordAuthor | Response prediction | - |
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