Publications
Detailed Information
Hypoxia-induced Maspin Expression Affects the Prognosis of Ovarian Clear Cell Carcinoma
Cited 2 time in
Web of Science
Cited 2 time in Scopus
- Authors
- Issue Date
- 2022-02-01
- Citation
- In Vivo, Vol.36 No.1, pp.212-220
- Abstract
- Background/Aim: To investigate the role of the expression of hypoxia-related genes on the prognosis of Methods: Basal mRNA levels of eight hypoxia-related genes were compared. Cell viability was assayed after treating ES2 cells under hypoxic conditions. The mRNA and protein levels were evaluated after the induction of hypoxia and administration of increased doses of N-acetylcysteine (NAC). Finally, the prognostic role of their expression levels was evaluated in 61 patients with OCCC. Results: The mRNA and protein levels of maspin increased gradually with the induction of hypoxia. Maspin protein expression decreased after treatment with paclitaxel and NAC. High expression of maspin was related to poor progression-free and overall survival in patients with OCCC (adjusted hazard ratios, 3.97 and 7.47; 95% confidence intervals=1.34-11.81, and 1.9828.13). Conclusion: High expression of maspin induced by hypoxia might be associated with poor prognosis of OCCC.
- ISSN
- 0258-851X
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.