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Heregulin-β1 Activates NF-E2-related Factor 2 and Induces Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells via Protein Kinase B and Extracellular Signal-regulated Protein Kinase Signaling Pathways : Heregulin-beta 1 Activates NF-E2-related Factor 2 and Induces Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells via Protein Kinase B and Extracellular Signal-regulated Protein Kinase Signaling Pathways
DC Field | Value | Language |
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dc.contributor.author | Park, Ji-Young | - |
dc.contributor.author | Saeidi, Soma | - |
dc.contributor.author | Kim, Eun-Hee | - |
dc.contributor.author | Kim, Do-Hee | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Keum, Joo-Seob | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2022-04-18T02:22:38Z | - |
dc.date.available | 2022-04-18T02:22:38Z | - |
dc.date.created | 2021-06-02 | - |
dc.date.created | 2021-06-02 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.citation | 대한암예방학회지, Vol.26 No.1, pp.54-63 | - |
dc.identifier.issn | 2288-3649 | - |
dc.identifier.other | 133983 | - |
dc.identifier.uri | https://hdl.handle.net/10371/178044 | - |
dc.description.abstract | Heregulin-beta 1, a ligand of ErbB-2 and ErbB-3/4 receptors, has been reported to potentiate oncogenicity and metastatic potential of breast cancer cells. In the present work, treatment of human mammary cancer (MCF-7) cells with heregulin-beta 1 resulted in enhanced cell migration and expression of manganese superoxide dismutase (MnSOD) and its mRNA transcript. Silencing of MnSOD abrogated clonogenicity and migrative ability of MCF-7 cells. Heregulin-beta 1 treatment also increased nuclear translocation, antioxidant response element binding and transcriptional activity of NF-E2-related factor 2 (Nrf2). A dominant-negative mutant of Nrf2 abrogated heregulin-beta 1-induced MnSOD expression. Treatment with heregulin-beta 1 caused activation of protein kinase B (Akt) and extracellular signal-regulated protein kinase (ERK). The pharmacological inhibitors of phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase 1/2, which are upstream of Akt and ERK, respectively, attenuated heregulin-beta 1-induced MnSOD expression and nuclear localization of Nrf2. In conclusion, heregulin-1 induces upregulation of MnSOD and activation of Nrf2 via the Akt and ERK signaling in MCF-7 cells, which may confer metastatic potential and invasiveness of these cells. | - |
dc.language | 영어 | - |
dc.publisher | 대한암예방학회 | - |
dc.title | Heregulin-β1 Activates NF-E2-related Factor 2 and Induces Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells via Protein Kinase B and Extracellular Signal-regulated Protein Kinase Signaling Pathways | - |
dc.title.alternative | Heregulin-beta 1 Activates NF-E2-related Factor 2 and Induces Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells via Protein Kinase B and Extracellular Signal-regulated Protein Kinase Signaling Pathways | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.15430/JCP.2021.26.1.54 | - |
dc.citation.journaltitle | 대한암예방학회지 | - |
dc.identifier.wosid | 000638883800006 | - |
dc.citation.endpage | 63 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 54 | - |
dc.citation.volume | 26 | - |
dc.identifier.sci | 000638883800006 | - |
dc.identifier.kciid | ART002697982 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 2 | - |
dc.subject.keywordPlus | ANTIOXIDANT-RESPONSE ELEMENT | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MNSOD EXPRESSION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | TUMORIGENICITY | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Heregulin-beta 1 | - |
dc.subject.keywordAuthor | Manganese superoxide dismutase | - |
dc.subject.keywordAuthor | NF-E2-related factor 2 | - |
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