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Stabilization of C/EBP beta through direct interaction with STAT3 in H-Ras transformed human mammary epithelial cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Lil-Li | - |
dc.contributor.author | Kim, Su-Jung | - |
dc.contributor.author | Hahn, Young-Il | - |
dc.contributor.author | Jang, Jeong-Hoon | - |
dc.contributor.author | Saeidi, Soma | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2022-04-18T02:22:58Z | - |
dc.date.available | 2022-04-18T02:22:58Z | - |
dc.date.created | 2021-05-18 | - |
dc.date.created | 2021-05-18 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, Vol.546, pp.130-137 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 131774 | - |
dc.identifier.uri | https://hdl.handle.net/10371/178059 | - |
dc.description.abstract | Signal transducer and activator of transcription 3 (STAT3) plays important roles in cancer-associated inflammation by controlling expression of proinflammatory cytokines and chemokines. Recent studies suggest that C/EBP13 (CCAAT-enhancer binding protein beta) and STAT3 synergistically stimulate cancer cell proliferation and epithelial-mesenchymal transition. C/EBP13 is a leucine-zipper transcription factor that regulates expression of a variety of inflammatory cytokines or chemokines, such as IL-8, G-CSF (granulocyte colony stimulating factor), and GM-CSF (granulocyte macrophage colony stimulating factor) which induce neutrophil infiltration and differentiation. However, molecular mechanisms by which STAT3 and C/EBP13 cooperatively interact had not been fully elucidated. In this study, we found that the level of C/EBP13 protein, but not that of its mRNA transcript, was decreased in the absence of STAT3 in H Ras transformed human mammary epithelial (H -Ras MCF10A) cells. In addition, silencing STAT3 dramatically induced ubiquitination of C/EBP13 for proteasomal degradation. Furthermore, direct inter action between STAT3 and C/EBP13 was confirmed by immunoprecipitation and proximity ligation assays. Taken together, these results suggest that STAT3 stabilizes C/EBP13, thereby promoting cancer-associated inflammation. (c) 2021 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Stabilization of C/EBP beta through direct interaction with STAT3 in H-Ras transformed human mammary epithelial cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.bbrc.2021.02.011 | - |
dc.citation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.wosid | 000624916600020 | - |
dc.identifier.scopusid | 2-s2.0-85100659179 | - |
dc.citation.endpage | 137 | - |
dc.citation.startpage | 130 | - |
dc.citation.volume | 546 | - |
dc.identifier.sci | 000624916600020 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | STAT3 | - |
dc.subject.keywordAuthor | C/EBP beta | - |
dc.subject.keywordAuthor | Cancer-associated inflammation | - |
dc.subject.keywordAuthor | H-ras MCF10A cells | - |
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