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Expression of human leukocyte antigen class I and beta 2-microglobulin in colorectal cancer and its prognostic impact
Cited 8 time in
Web of Science
Cited 8 time in Scopus
- Authors
- Issue Date
- 2021-01
- Publisher
- Oxford University Press
- Citation
- Cancer Science, Vol.112 No.1, pp.91-100
- Abstract
- Downregulation of human leukocyte antigen (HLA) class I has been postulated to be a mechanism of adaptive immune escape in various tumors, especially microsatellite instability-high (MSI-H) colorectal cancer (CRC). In this study, we aimed to investigate HLA class I and beta 2-microglobulin (beta 2M) expression in MSI-H and microsatellite-stable (MSS) CRCs and determine its prognostic impact. The representative areas from the tumor center (TC) and tumor periphery (TP) from 300 CRCs, including 161 MSI-H and 139 MSS cases, were selected to construct a tissue microarray. Immunohistochemistry (IHC) for HLA A/B/C, beta 2M, CD3, and CD8 was performed. Reduced HLA A/B/C expression was detected in 113 (70.2%) MSI-H and 54 (38.8%) MSS cases, while reduced beta 2M expression was observed in 69 (42.9%) MSI-H and 17 (12.2%) MSS cases. Although reduced beta 2M expression was associated with higher pathological tumor (pT) stage in MSI-H CRC with borderline significance, no association was found between HLA A/B/C and beta 2M expression and survival. Interestingly, reduced HLA A/B/C expression in MSS was associated with higher stage, and reduced HLA A/B/C and beta 2M expression was an independent prognostic factor in multivariate analysis. In conclusion, reduced HLA A/B/C and beta 2M expression was frequently observed in immunotherapy-naive MSI-H CRC, suggesting the possibility of primary resistance to immune checkpoint inhibitor. Interestingly, downregulation of HLA A/B/C and beta 2M was associated with poor prognosis in MSS cancers. Overall, IHC for HLA A/B/C and beta 2M might be a feasible predictive or prognostic tool in CRC.
- ISSN
- 1347-9032
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