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Novel prognostic classification predicts overall survival of patients receiving salvage whole-brain radiotherapy for recurrent brain metastasis from breast cancer: A recursive partitioning analysis (KROG 16-12)
DC Field | Value | Language |
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dc.contributor.author | Kim, Jae Sik | - |
dc.contributor.author | Kim, Kyubo | - |
dc.contributor.author | Jung, Wonguen | - |
dc.contributor.author | Shin, Kyung Hwan | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, Yong Bae | - |
dc.contributor.author | Chang, Jee Suk | - |
dc.contributor.author | Choi, Doo Ho | - |
dc.contributor.author | Kim, Haeyoung | - |
dc.contributor.author | Park, Yeon Hee | - |
dc.contributor.author | Kim, Dae Yong | - |
dc.contributor.author | Kim, Tae Hyun | - |
dc.contributor.author | Kwon, Jeanny | - |
dc.contributor.author | Kang, Ki Mun | - |
dc.contributor.author | Chung, Woong-Ki | - |
dc.contributor.author | Kim, Kyung Su | - |
dc.contributor.author | Kim, In Ah | - |
dc.date.accessioned | 2022-04-26T07:12:14Z | - |
dc.date.available | 2022-04-26T07:12:14Z | - |
dc.date.created | 2021-12-27 | - |
dc.date.created | 2021-12-27 | - |
dc.date.created | 2021-12-27 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.citation | Breast, Vol.60, pp.272-278 | - |
dc.identifier.issn | 0960-9776 | - |
dc.identifier.other | 153114 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179232 | - |
dc.description.abstract | Background: To investigate outcomes of salvage whole-brain radiotherapy (WBRT) for recurrent brain metastases (BM) from breast cancer (BC), to identify prognostic factors of overall survival (OS), and to propose a novel prognostic classification for OS in these patients. Materials and methods: We identified 54 patients who had received salvage WBRT as the second brain-focused treatment for recurrent BM from BC (2000-2014). The median follow-up duration was 4.9 months. A recursive partitioning analysis (RPA) was conducted to develop a model to predict OS at the time of salvage WBRT. Results: The median OS was 6.8 months. OS according to BC-specific graded prognostic assessment (breast-GPA), modified breast-GPA, and updated breast-GPA did not represent our cohort. In the multivariate analysis, a long time before salvage WBRT (>= 16 months), control of primary BC or extracranial metastases, systemic treatment after salvage WBRT, and administration of a biologically effective dose for an alpha/beta of 10 Gy (BED10) of salvage WBRT >37.5 Gy showed superior OS. We proposed three RPA classes based on the control of both primary BC and extracranial metastasis and BED10 of salvage WBRT: class I, class II, and class III. In this model, patients with class I experienced the best OS (34.6 months; class II, 5.0 months; class III, 2.4 months; P < 0.001). Conclusions: In our RPA classification according to the control of both primary BC and extracranial metastasis and the dose of salvage WBRT, significant differences in OS were observed. The subsequent use of a systemic treatment showed better OS. (C) 2021 The Authors. Published by Elsevier Ltd. | - |
dc.language | 영어 | - |
dc.publisher | Churchill Livingstone | - |
dc.title | Novel prognostic classification predicts overall survival of patients receiving salvage whole-brain radiotherapy for recurrent brain metastasis from breast cancer: A recursive partitioning analysis (KROG 16-12) | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1016/j.breast.2021.11.005 | - |
dc.citation.journaltitle | Breast | - |
dc.identifier.wosid | 000744958000036 | - |
dc.identifier.scopusid | 2-s2.0-85119284069 | - |
dc.citation.endpage | 278 | - |
dc.citation.startpage | 272 | - |
dc.citation.volume | 60 | - |
dc.identifier.sci | 000744958000036 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Shin, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Kim, In Ah | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | STEREOTACTIC RADIOSURGERY | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | REIRRADIATION | - |
dc.subject.keywordPlus | TRASTUZUMAB | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Brain metastasis | - |
dc.subject.keywordAuthor | Whole-brain radiotherapy | - |
dc.subject.keywordAuthor | Overall survival | - |
dc.subject.keywordAuthor | Recursive partitioning analysis | - |
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