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p Oncologic outcomes according to the location and status of resection margin in pancreas head cancer: role of radiation therapy in R1 resection
DC Field | Value | Language |
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dc.contributor.author | Sohn, Hee Ju | - |
dc.contributor.author | Kim, Hongbeom | - |
dc.contributor.author | Kim, Sun Joo | - |
dc.contributor.author | Lee, Kyung Bun | - |
dc.contributor.author | Han, Youngmin | - |
dc.contributor.author | Lee, Jung Min | - |
dc.contributor.author | Kang, Jae Seung | - |
dc.contributor.author | Kwon, Wooil | - |
dc.contributor.author | Chie, Eui Kyu | - |
dc.contributor.author | Kim, Haeryoung | - |
dc.contributor.author | Jang, Jin-Young | - |
dc.date.accessioned | 2022-05-04T01:46:25Z | - |
dc.date.available | 2022-05-04T01:46:25Z | - |
dc.date.created | 2022-02-07 | - |
dc.date.issued | 2022-01-01 | - |
dc.identifier.citation | 대한외과학회지, Vol.102 No.1, pp.10-19 | - |
dc.identifier.issn | 2288-6575 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179392 | - |
dc.description.abstract | Purpose: The clinical significance of margin status in pancreatic head cancer is still controversial due to the nonstandardized definition of R status and pathologic reporting. This study aims to evaluate the impact of the margin status including location and the role of radiation therapy in pancreatic head cancer. Methods: A total of 314 patients who underwent curative-intent surgery for pancreatic head cancer between 2010 and 2017 were analyzed. Demographics, survival, and local recurrences were compared according to 2 definitions: 0-mm R1 as direct involvement and 1-mm R1 as close resection margin less than 1 mm. The specific margins were divided into 4 groups according to the location around the pancreas: pancreas transection, anterior surface, posterior surface, and vessel (superior mesenteric artery/superior mesenteric vein) margin. Results: The 0-mm R1-rate was 15.6%, and increased to 36.3% in 1-mm R1. The median overall survival rate of 0-mm R0 vs. R1 was 26 months vs. 16 months (P = 0.052) and that of 1-mm R0 vs. R1 was 27 months vs. 18 months, respectively (P = 0.016). In individual margins, posterior, anterior surface, and pancreas transection margin involvement were associated with poor outcome, and the 1 mm posterior surface involvement was an independent risk factor for disease-free survival (hazard ratio, 1.63). Adjuvant radiation therapy had oncologic benefits, especially in R1 patients (P = 0.011) compared to R0 patients (P = 0.088). Conclusion: Margin status, especially 1-mm R1 status is an important predictive factor, and involved posterior surface has a clinical impact. Patients with positive margins should be considered adjuvant radiation therapy. | - |
dc.language | 영어 | - |
dc.publisher | 대한외과학회 | - |
dc.title | p Oncologic outcomes according to the location and status of resection margin in pancreas head cancer: role of radiation therapy in R1 resection | - |
dc.type | Article | - |
dc.identifier.doi | 10.4174/astr.2022.102.1.10 | - |
dc.citation.journaltitle | 대한외과학회지 | - |
dc.identifier.wosid | 000744053900002 | - |
dc.identifier.scopusid | 2-s2.0-85123540004 | - |
dc.citation.endpage | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 10 | - |
dc.citation.volume | 102 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Hongbeom | - |
dc.contributor.affiliatedAuthor | Chie, Eui Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Haeryoung | - |
dc.contributor.affiliatedAuthor | Jang, Jin-Young | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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