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Polyhexamethylene guanidine phosphate increases stress granule formation in human 3D lung organoids under respiratory syncytial virus infection
DC Field | Value | Language |
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dc.contributor.author | Choi, Seri | - |
dc.contributor.author | Choi, Sunkyung | - |
dc.contributor.author | Choi, Yeongsoo | - |
dc.contributor.author | Cho, Namjoon | - |
dc.contributor.author | Kim, Seung-Yeon | - |
dc.contributor.author | Lee, Chang Hyun | - |
dc.contributor.author | Park, Han-Jin | - |
dc.contributor.author | Oh, Won Keun | - |
dc.contributor.author | Kim, Kee K. | - |
dc.contributor.author | Kim, Eun-Mi | - |
dc.date.accessioned | 2022-05-16T08:49:22Z | - |
dc.date.available | 2022-05-16T08:49:22Z | - |
dc.date.created | 2022-01-17 | - |
dc.date.created | 2022-01-17 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.citation | Ecotoxicology and Environmental Safety, Vol.229, p. 113094 | - |
dc.identifier.issn | 0147-6513 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179777 | - |
dc.description.abstract | Polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, is known to cause lung toxicity, including inflammation and pulmonary fibrosis. In this study, we aimed to investigate the effect of PHMG-p on human lung tissue models (2D epithelial cells and 3D organoids) under conditions of oxidative stress and viral infection. The effect of PHMG-p was studied by evaluating the formation of stress granules (SGs), which play a pivotal role in cellular adaptation to various stress conditions. Under oxidative stress and respiratory syncytial virus (RSV) infection, exposure to PHMG-p remarkably increased eIF2a phosphorylation, which is essential for SG-related signalling, and significantly increased SG formation. Furthermore, PHMG-p induced fibrotic gene expression and caused cell death due to severe DNA damage, which was further increased under oxidative stress and RSV infection, indicating that PHMG-p induces severe lung toxicity under stress conditions. Taken together, toxicity evaluation under various stressful conditions is necessary to accurately predict potential lung toxicity of chemicals affecting the respiratory tract. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Polyhexamethylene guanidine phosphate increases stress granule formation in human 3D lung organoids under respiratory syncytial virus infection | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ecoenv.2021.113094 | - |
dc.citation.journaltitle | Ecotoxicology and Environmental Safety | - |
dc.identifier.wosid | 000740097500010 | - |
dc.identifier.scopusid | 2-s2.0-85121454759 | - |
dc.citation.startpage | 113094 | - |
dc.citation.volume | 229 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Won Keun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | TRANSLATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | HYDROCHLORIDE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | EIF-2-ALPHA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INTERACTS | - |
dc.subject.keywordAuthor | DNA damage | - |
dc.subject.keywordAuthor | eIF2 alpha | - |
dc.subject.keywordAuthor | Stress granules | - |
dc.subject.keywordAuthor | Polyhexamethylene guanidine phosphate | - |
dc.subject.keywordAuthor | Lung organoids | - |
dc.subject.keywordAuthor | Pulmonary fibrosis | - |
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