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Impact of pitavastatin on new-onset diabetes mellitus compared to atorvastatin and rosuvastatin: a distributed network analysis of 10 real-world databases
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Won‑Woo Seo | - |
dc.contributor.author | Seung In Seo | - |
dc.contributor.author | Yerim Kim | - |
dc.contributor.author | Jong Jin Yoo | - |
dc.contributor.author | Woon Geon Shin | - |
dc.contributor.author | Jinseob Kim | - |
dc.contributor.author | Seng Chan You | - |
dc.contributor.author | Rae Woong Park | - |
dc.contributor.author | Young Min Park | - |
dc.contributor.author | Kyung‑Jin Kim | - |
dc.contributor.author | Sang Youl Rhee | - |
dc.contributor.author | Meeyoung Park | - |
dc.contributor.author | Eun‑Sun Jin | - |
dc.contributor.author | Sung Eun Kim | - |
dc.date.accessioned | 2022-06-13T04:32:47Z | - |
dc.date.available | 2022-06-13T04:32:47Z | - |
dc.date.issued | 2022-05-23 | - |
dc.identifier.citation | Cardiovascular Diabetology. Vol 21(1):82 | ko_KR |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.uri | https://hdl.handle.net/10371/181271 | - |
dc.description.abstract | Statin treatment increases the risk of new-onset diabetes mellitus (NODM); however, data directly comparing the risk of NODM among individual statins is limited. We compared the risk of NODM between patients using pitavastatin and atorvastatin or rosuvastatin using reliable, large-scale data.
Data of electronic health records from ten hospitals converted to the Observational Medical Outcomes Partnership Common Data Model (n = 14,605,368 patients) were used to identify new users of pitavastatin, atorvastatin, or rosuvastatin (atorvastatin + rosuvastatin) for ≥ 180 days without a previous history of diabetes or HbA1c level ≥ 5.7%. We conducted a cohort study using Cox regression analysis to examine the hazard ratio (HR) of NODM after propensity score matching (PSM) and then performed an aggregate meta-analysis of the HR. After 1:2 PSM, 10,238 new pitavastatin users (15,998 person-years of follow-up) and 18,605 atorvastatin + rosuvastatin users (33,477 person-years of follow-up) were pooled from 10 databases. The meta-analysis of the HRs demonstrated that pitavastatin resulted in a significantly reduced risk of NODM than atorvastatin + rosuvastatin (HR 0.72; 95% CI 0.59–0.87). In sub-analysis, pitavastatin was associated with a lower risk of NODM than atorvastatin or rosuvastatin after 1:1 PSM (HR 0.69; CI 0.54–0.88 and HR 0.74; CI 0.55–0.99, respectively). A consistently low risk of NODM in pitavastatin users was observed when compared with low-to-moderate-intensity atorvastatin + rosuvastatin users (HR 0.78; CI0.62–0.98). In this retrospective, multicenter active-comparator, new-user, cohort study, pitavastatin reduced the risk of NODM compared with atorvastatin or rosuvastatin. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Diabetes mellitus | - |
dc.subject | Pitavastatin | - |
dc.subject | Statin | - |
dc.subject | Common data model | - |
dc.title | Impact of pitavastatin on new-onset diabetes mellitus compared to atorvastatin and rosuvastatin: a distributed network analysis of 10 real-world databases | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | https://doi.org/10.1186/s12933-022-01524-6 | ko_KR |
dc.citation.journaltitle | Cardiovascular Diabetology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2022-05-29T03:32:56Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 82 | ko_KR |
dc.citation.volume | 21 | ko_KR |
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