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Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches
DC Field | Value | Language |
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dc.contributor.author | Lee, Amos C. | - |
dc.contributor.author | Lee, Yongju | - |
dc.contributor.author | Choi, Ahyoun | - |
dc.contributor.author | Lee, Han-Byoel | - |
dc.contributor.author | Shin, Kyoungseob | - |
dc.contributor.author | Lee, Hyunho | - |
dc.contributor.author | Kim, Ji Young | - |
dc.contributor.author | Ryu, Han Suk | - |
dc.contributor.author | Kim, Hoe Suk | - |
dc.contributor.author | Ryu, Seung Yeon | - |
dc.contributor.author | Lee, Sangeun | - |
dc.contributor.author | Cheun, Jong-Ho | - |
dc.contributor.author | Yoo, Duck Kyun | - |
dc.contributor.author | Lee, Sumin | - |
dc.contributor.author | Choi, Hansol | - |
dc.contributor.author | Ryu, Taehoon | - |
dc.contributor.author | Yeom, Huiran | - |
dc.contributor.author | Kim, Namphil | - |
dc.contributor.author | Noh, Jinsung | - |
dc.contributor.author | Lee, Yonghee | - |
dc.contributor.author | Kim, Inyoung | - |
dc.contributor.author | Bae, Sangwook | - |
dc.contributor.author | Kim, Jinhyun | - |
dc.contributor.author | Lee, Wooseok | - |
dc.contributor.author | Kim, Okju | - |
dc.contributor.author | Jung, Yushin | - |
dc.contributor.author | Kim, Changhoe | - |
dc.contributor.author | Song, Seo Woo | - |
dc.contributor.author | Choi, Yeongjae | - |
dc.contributor.author | Chung, Junho | - |
dc.contributor.author | Kim, Byung Gee | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Kwon, Sunghoon | - |
dc.date.accessioned | 2022-06-21T08:02:33Z | - |
dc.date.available | 2022-06-21T08:02:33Z | - |
dc.date.created | 2022-05-24 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.citation | Nature Communications, Vol.13 No.1, p. 2540 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://hdl.handle.net/10371/182642 | - |
dc.description.abstract | Epitranscriptomic features, such as single-base RNA editing, are sources of transcript diversity in cancer, but little is understood in terms of their spatial context in the tumour microenvironment. Here, we introduce spatial-histopathological examination-linked epitranscriptomics converged to transcriptomics with sequencing (Select-seq), which isolates regions of interest from immunofluorescence-stained tissue and obtains transcriptomic and epitranscriptomic data. With Select-seq, we analyse the cancer stem cell-like microniches in relation to the tumour microenvironment of triple-negative breast cancer patients. We identify alternative splice variants, perform complementarity-determining region analysis of infiltrating T cells and B cells, and assess adenosine-to-inosine base editing in tumour tissue sections. Especially, in triple-negative breast cancer microniches, adenosine-to-inosine editome specific to different microniche groups is identified. The spatial context of epitranscriptomic features in the tumour microenvironment remains poorly understood. Here, a method for transcriptomic and epitranscriptomic analysis of immunofluorescence-stained tissue, Select-seq, is applied to stem cell-like microniches in triple negative breast cancer. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-022-30299-3 | - |
dc.citation.journaltitle | Nature Communications | - |
dc.identifier.wosid | 000792848500013 | - |
dc.identifier.scopusid | 2-s2.0-85129516649 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 2540 | - |
dc.citation.volume | 13 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chung, Junho | - |
dc.contributor.affiliatedAuthor | Kim, Byung Gee | - |
dc.contributor.affiliatedAuthor | Han, Wonshik | - |
dc.contributor.affiliatedAuthor | Kwon, Sunghoon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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