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The Anti-Atherosclerosis Effect of Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, in Apolipoprotein E Knockout Mice
DC Field | Value | Language |
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dc.contributor.author | Ku, Eu Jeong | - |
dc.contributor.author | Kim, Bo-Rahm | - |
dc.contributor.author | Lee, Jee-In | - |
dc.contributor.author | Lee, Yun Kyung | - |
dc.contributor.author | Oh, Tae Jung | - |
dc.contributor.author | Jang, Hak C. | - |
dc.contributor.author | Choi, Sung Hee | - |
dc.date.accessioned | 2022-06-21T08:16:44Z | - |
dc.date.available | 2022-06-21T08:16:44Z | - |
dc.date.created | 2022-05-31 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.citation | International Journal of Molecular Sciences, Vol.23 No.9 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://hdl.handle.net/10371/182656 | - |
dc.description.abstract | Interleukin (IL)-1 beta plays an important role in atherosclerosis pathogenesis. We aimed to investigate the effect of anakinra, a recombinant human IL-1 receptor antagonist, on the progression of atherosclerosis in apolipoprotein E knockout (ApoE(-/-)) mice. ApoE(-/-) mice (8-week male) were treated with saline (control), anakinra 10, 25, and 50 mg/kg, respectively (n = 10 in each group). Mice were fed a standard chow (4 weeks) followed by an atherogenic diet (35kcal% fat, 1.25% cholesterol, 12 weeks). Atheromatous plaques in ApoE(-/-) mice and the expression of inflammatory genes and signaling pathways in human umbilical vein endothelial cells (HUVECs), rat aortic smooth muscle cells (RAOSMCs), and 3T3-L1 adipocytes were assessed. Anakinra reduced the plaque size of the aortic arch (30.6% and 25.2% at the 25 mg/kg and 50 mg/kg doses, both p < 0.05) and serum triglyceride in ApoE(-/-) mice and suppressed inflammatory genes (IL-1 beta and IL-6) expressions in HUVECs and RAOSMCs (all p < 0.05). In RAOSMCs, anakinra reduced metalloproteinase-9 expression in a dose-dependent manner and inhibited cell migration. Anakinra-treated mice exhibited trends of lower CD68+ macrophage infiltration in visceral fat and monocyte chemoattractant protein-1 expression was reduced in 3T3-L1 adipocytes. Anakinra could be a useful component for complementary treatment with a standard regimen to reduce the residual cardiovascular risk. | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | The Anti-Atherosclerosis Effect of Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, in Apolipoprotein E Knockout Mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms23094906 | - |
dc.citation.journaltitle | International Journal of Molecular Sciences | - |
dc.identifier.wosid | 000796110000001 | - |
dc.identifier.scopusid | 2-s2.0-85129003871 | - |
dc.citation.number | 9 | - |
dc.citation.volume | 23 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Jang, Hak C. | - |
dc.contributor.affiliatedAuthor | Choi, Sung Hee | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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