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Vitamin D status in Dupuytren's disease: Association with clinical status and vitamin D receptor expression
DC Field | Value | Language |
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dc.contributor.author | Park, Jin Woo | - |
dc.contributor.author | Kim, Sung Taeck | - |
dc.contributor.author | Lee, Kyu Sang | - |
dc.contributor.author | Gong, Hyun Sik | - |
dc.date.accessioned | 2022-06-24T00:27:55Z | - |
dc.date.available | 2022-06-24T00:27:55Z | - |
dc.date.created | 2022-05-12 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.citation | Journal of Plastic, Reconstructive and Aesthetic Surgery | - |
dc.identifier.issn | 1748-6815 | - |
dc.identifier.uri | https://hdl.handle.net/10371/183841 | - |
dc.description.abstract | © 2022 Elsevier LtdBackground: Dupuytren's disease (DD) is a progressive fibroproliferative condition involving contractures of the fascia of the palm. Up to now, there are no relevant investigations on patients with DD in case of serum vitamin D deficiency. We hypothesized that transforming growth factor-β1 (TGF-β1) is increased in patients with DD in consequence of vitamin D deficiency, thereby leading to myofibroblast differentiation and subsequent progression of contractures. Methods: The aim of this study was to analyze serum vitamin D levels and explore possible clinical and immunohistochemical correlates with vitamin D concentrations in a group of patients with DD. Vitamin D levels were measured in all patients with DD and healthy controls. In the patient group, clinical characteristics were compared between vitamin D deficient and nondeficient subgroups. Diseased palmar fascia samples were obtained from 14 patients undergoing fasciectomy for DD. Correlations between vitamin D levels and vitamin D receptor(VDR), TGF-β1 expression levels in collected fascia samples were evaluated. Results: Vitamin D concentrations were significantly lower in patients than in healthy controls. In addition, total extension deficit of involved fingers was higher in vitamin D deficient patients. Moreover, a positive correlation was found between vitamin D levels and expression of VDR in pathologic fascia in patients undergoing fasciectomy for contracture. Serum vitamin D levels were found to be low in patients with DD. Expression of VDR was lower in the vitamin D deficient group. Conclusions: The results suggest a potential link between vitamin D status and DD but causation is not yet established. The potential role of vitamin D and its interaction with VDR and the TGF-β1 signaling pathway in the pathogenesis of DD needs to be explored further. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Vitamin D status in Dupuytren's disease: Association with clinical status and vitamin D receptor expression | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bjps.2022.01.012 | - |
dc.citation.journaltitle | Journal of Plastic, Reconstructive and Aesthetic Surgery | - |
dc.identifier.scopusid | 2-s2.0-85124136770 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Gong, Hyun Sik | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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