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Mouse Model of Small for Gestational Age Offspring with Catch-up Growth Failure and Dysregulated Glucose Metabolism in Adulthood
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Hyeon Seok | - |
dc.contributor.author | Kim, Hanbin | - |
dc.contributor.author | Kim, Bohye | - |
dc.contributor.author | Kim, Min-Seon | - |
dc.contributor.author | Kim, Jae Hyun | - |
dc.contributor.author | Kwon, Obin | - |
dc.date.accessioned | 2022-06-24T01:17:42Z | - |
dc.date.available | 2022-06-24T01:17:42Z | - |
dc.date.created | 2022-05-17 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.citation | Journal of Obesity & Metabolic Syndrome, Vol.31 No.1, pp.81-85 | - |
dc.identifier.issn | 2508-6235 | - |
dc.identifier.uri | https://hdl.handle.net/10371/183971 | - |
dc.description.abstract | Background: We aimed to build mouse models of small for gestational age (SGA), recapitulating failure of catch-up growth and dysregulated metabolic outcomes in adulthood. Methods: Pregnant CS7BU6 mice were given a protein-restricted diet (PRD; 6% kcal from protein) during pregnancy without (model 1) or with cross-fostering (model 2). Model 3 extended the PRD to the end of the lactation period. Model 4 changed to a 93'o PRD without cross-fostering. Results: Model 1 yielded a reduced size of offspring with a poor survival rate. Model 2 improved survival but offspring showed early catch-up growth. Model 3 maintained a reduced size of offspring after weaning with a higher body mass index and blood glucose levels in adult stages. Model 4 increased the survival of the offspring while maintaining a reduced size and dysregulated glucose metabolism. Conclusion: Models 3 and 4 are suitable for studying SGA accompanying adulthood short stature and metabolic disorders. | - |
dc.language | 영어 | - |
dc.publisher | 대한비만학회 | - |
dc.title | Mouse Model of Small for Gestational Age Offspring with Catch-up Growth Failure and Dysregulated Glucose Metabolism in Adulthood | - |
dc.type | Article | - |
dc.identifier.doi | 10.7570/jomes22013 | - |
dc.citation.journaltitle | Journal of Obesity & Metabolic Syndrome | - |
dc.identifier.wosid | 000786289800006 | - |
dc.identifier.scopusid | 2-s2.0-85129097607 | - |
dc.citation.endpage | 85 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 81 | - |
dc.citation.volume | 31 | - |
dc.identifier.kciid | ART002823182 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Kwon, Obin | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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