Publications
Detailed Information
Hypothetical role of hypoxia-inducible factor-1 in adaptations to microgravity Papel hipotético del factor 1 inducible por hipoxia en las adaptaciones a la microgravedad
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chun, Yang-Sook | - |
dc.contributor.author | Hargens, Alan R. | - |
dc.date.accessioned | 2022-06-24T07:16:28Z | - |
dc.date.available | 2022-06-24T07:16:28Z | - |
dc.date.created | 2022-05-03 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.citation | Revista Cubana de Investigaciones Biomedicas, Vol.38 No.3 | - |
dc.identifier.issn | 0864-0300 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184034 | - |
dc.description.abstract | © 2019, Editorial Ciencias Medicas. All rights reserved.Maintaining health in microgravity and overcoming environmental hazards such as cosmic radiation are essential for long-term space flight. Recent studies have focused on the involvement of hypoxia-inducible factor (HIF)-1 in altered gravity using cell-based or in vivo mouse model systems. HIF-1alpha and its target downstream gene expression are differentially expressed in hypergravity and microgravity. Nevertheless, underlying molecular mechanism of HIF-1alpha involvement is still unclear. Herein, we analyzed the 2019 Science paper by Garrett-Bakelman and coauthors in which NASA performed multidimensional analyses of long-term human spaceflight in identical twin astronauts. Correlations were found between the expression of HIF-1alpha related cytokines and prolonged space flight. We hypothesize that HIF-1alpha is a molecular target for the development of therapeutics to prevent the detrimental effects of microgravity and cosmic radiation on astronauts during long-term space flight. | - |
dc.language | 영어 | - |
dc.publisher | Editorial Ciencias Medicas | - |
dc.title | Hypothetical role of hypoxia-inducible factor-1 in adaptations to microgravity Papel hipotético del factor 1 inducible por hipoxia en las adaptaciones a la microgravedad | - |
dc.type | Article | - |
dc.citation.journaltitle | Revista Cubana de Investigaciones Biomedicas | - |
dc.identifier.scopusid | 2-s2.0-85073750066 | - |
dc.citation.number | 3 | - |
dc.citation.volume | 38 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chun, Yang-Sook | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.