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Ethanol Extract of Sargassum siliquastrum Inhibits Lipopolysaccharide-Induced Nitric Oxide Generation by Downregulating the Nuclear Factor-Kappa B Signaling Pathway
DC Field | Value | Language |
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dc.contributor.author | Min, Hye-Young | - |
dc.contributor.author | Kim, Hyewon | - |
dc.contributor.author | Lee, Ho Jin | - |
dc.contributor.author | Yoon, Na-Young | - |
dc.contributor.author | Kim, Yeon-Kye | - |
dc.contributor.author | Lee, Ho-Young | - |
dc.date.accessioned | 2022-09-28T01:21:41Z | - |
dc.date.available | 2022-09-28T01:21:41Z | - |
dc.date.created | 2022-07-13 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | Evidence-based Complementary and Alternative Medicine, Vol.2022, p. 6160010 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.uri | https://hdl.handle.net/10371/184492 | - |
dc.description.abstract | Sargassum siliquastrum (SS) is an edible brown seaweed widely consumed in Korea and considered a functional food source. Previous studies have reported various biological activities of SS extracts, including antioxidant and hepatoprotective properties. In the present study, we examined the anti-inflammatory effects of the SS extract and assessed the underlying mechanism of action. The SS extract significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production in a dose-dependent manner (% of NO production at 500 mu g/mL: 60.1 +/- 0.9%), with no obvious toxicity. Furthermore, the SS extract inhibited mRNA and protein expression levels of inducible NO synthase, as well as LPS-induced expression and production of proinflammatory cytokines such as IL-1 beta, IL-6, or TNF-alpha (IL-6 production (ng/mL) : LPS-: 0.7 +/- 0.3; LPS+: 68.1 +/- 2.8; LPS + SS extract: 51.9 +/- 1.2; TNF-alpha production (ng/mL) : LPS-: 0.3 +/- 0.1; LPS+: 23.0 +/- 0.1; LPS + SS extract: 18.2 +/- 10.8). Mechanistically, the SS extract attenuated LPS-induced activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (nuclear factor-kappa B, NF-kappa B) signaling pathway such as phosphorylation of NF-kappa B p65 and degradation of I kappa B-alpha, thereby blocking LPS-induced activation of NF-kappa B transcriptional activity. The SS extract also enhanced LPS-induced heme oxygenase-1 expression and attenuated LPS-induced cellular reactive oxygen species production (% of ROS production at 500 mu g/mL: 52.2 +/- 1.3%). Collectively, these findings suggest that the SS extract elicits anti-inflammatory effects in mouse macrophage cells. | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press | - |
dc.title | Ethanol Extract of Sargassum siliquastrum Inhibits Lipopolysaccharide-Induced Nitric Oxide Generation by Downregulating the Nuclear Factor-Kappa B Signaling Pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.1155/2022/6160010 | - |
dc.citation.journaltitle | Evidence-based Complementary and Alternative Medicine | - |
dc.identifier.wosid | 000813939600005 | - |
dc.identifier.scopusid | 2-s2.0-85132511762 | - |
dc.citation.startpage | 6160010 | - |
dc.citation.volume | 2022 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Ho Jin | - |
dc.contributor.affiliatedAuthor | Lee, Ho-Young | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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