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Association Between Systolic Blood Pressure Variability and Major Adverse Cardiovascular Events in Korean Patients With Chronic Kidney Disease: Findings From KNOW-CKD
DC Field | Value | Language |
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dc.contributor.author | Park, Cheol Ho | - |
dc.contributor.author | Kim, Hyung Woo | - |
dc.contributor.author | Joo, Young Su | - |
dc.contributor.author | Park, Jung Tak | - |
dc.contributor.author | Chang, Tae Ik | - |
dc.contributor.author | Yoo, Tae-Hyun | - |
dc.contributor.author | Park, Sue Kyung | - |
dc.contributor.author | Chae, Dong-Wan | - |
dc.contributor.author | Chung, Wookyung | - |
dc.contributor.author | Kim, Yong-Soo | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.contributor.author | Kang, Shin-Wook | - |
dc.contributor.author | Han, Seung Hyeok | - |
dc.date.accessioned | 2022-09-29T03:18:25Z | - |
dc.date.available | 2022-09-29T03:18:25Z | - |
dc.date.created | 2022-06-29 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | Journal of the American Heart Association, Vol.11 No.11, p. e025513 | - |
dc.identifier.issn | 2047-9980 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184644 | - |
dc.description.abstract | BACKGROUND: Whether visit-to-visit systolic blood pressure (SBP) variability can predict major adverse cardiovascular events (MACE) in patients with chronic kidney disease is unclear. METHODS AND RESULTS: We investigated the relationship between SDs of visit-to-visit SBP variability during the first year of enrollment and MACE among 1575 participants from KNOW-CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease). Participants were categorized into 3 groups according to tertiles of visit-to-visit SBP variability (SD). The study end point was MACE, defined as a composite of nonfatal myocardial infarction, unstable angina, revascularization, nonfatal stroke, hospitalization for heart failure, or cardiac death. During 6748 patient-years of follow-up (median, 4.2 years), MACE occurred in 64 participants (4.1%). Compared with the lowest tertile of visit-to-visit SBP variability (SD), the hazard ratios (HRs) for the middle and the highest tertile were 1.64 (95% CI, 0.80-3.36) and 2.23 (95% CI, 1.12-4.44), respectively, in a multivariable cause-specific hazard model. In addition, the HR associated with each 5-mm Hg increase in visit-to-visit SBP variability (SD) was 1.21 (95% CI, 1.01-1.45). This association was consistent in sensitivity analyses with 2 additional definitions of SBP variability determined by the coefficient of variation and variation independent of the mean. The corresponding HRs for the middle and highest tertiles were 2.11 (95% CI, 1.03-4.35) and 2.28 (95% CI, 1.12-4.63), respectively, in the analysis with the coefficient of variation and 1.76 (95% CI, 0.87-3.57) and 2.04 (95% CI, 1.03-4.03), respectively, with the variation independent of the mean. CONCLUSIONS: Higher visit-to-visit SBP variability is associated with an increased risk of MACE in patients with chronic kidney disease. | - |
dc.language | 영어 | - |
dc.publisher | Wiley-Blackwell | - |
dc.title | Association Between Systolic Blood Pressure Variability and Major Adverse Cardiovascular Events in Korean Patients With Chronic Kidney Disease: Findings From KNOW-CKD | - |
dc.type | Article | - |
dc.identifier.doi | 10.1161/JAHA.122.025513 | - |
dc.citation.journaltitle | Journal of the American Heart Association | - |
dc.identifier.wosid | 000807022400003 | - |
dc.identifier.scopusid | 2-s2.0-85132271305 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | e025513 | - |
dc.citation.volume | 11 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Oh, Kook-Hwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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