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Antibody Responses to SARS-CoV-2 in Children With COVID-19
DC Field | Value | Language |
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dc.contributor.author | Han, Mi Seon | - |
dc.contributor.author | Um, Jihye | - |
dc.contributor.author | Lee, Eun Joo | - |
dc.contributor.author | Kim, Kyung Min | - |
dc.contributor.author | Chang, Sung Hee | - |
dc.contributor.author | Lee, Hyunju | - |
dc.contributor.author | Kim, Ye Kyung | - |
dc.contributor.author | Choi, Youn Young | - |
dc.contributor.author | Cho, Eun Young | - |
dc.contributor.author | Kim, Dong Hyun | - |
dc.contributor.author | Choi, Jae Hong | - |
dc.contributor.author | Lee, Jina | - |
dc.contributor.author | Kim, Misuk | - |
dc.contributor.author | Chung, Ki-Hyun | - |
dc.contributor.author | Min, Hye Sook | - |
dc.contributor.author | Choe, Young June | - |
dc.contributor.author | Lim, Dong-Gyun | - |
dc.contributor.author | Park, Jun-Sun | - |
dc.contributor.author | Choi, Eun Hwa | - |
dc.date.accessioned | 2022-09-29T03:18:56Z | - |
dc.date.available | 2022-09-29T03:18:56Z | - |
dc.date.created | 2022-07-18 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | Journal of the Pediatric Infectious Diseases Society, Vol.11 No.6, pp.267-273 | - |
dc.identifier.issn | 2048-7207 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184683 | - |
dc.description.abstract | © The Author(s) 2022. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.BACKGROUND: The immunologic features of children with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not clearly delineated. This study was conducted to evaluate SARS-CoV-2-specific antibody responses in children with COVID-19. METHODS: The levels of anti-spike (S) IgG, anti-SARS-CoV-2 IgG, and neutralizing antibody (NAb) were measured during various time points in children <19 years of age with COVID-19 in South Korea from February 2020 to September 2020. RESULTS: One hundred sixty-five blood samples from 114 children with COVID-19 (43.9% asymptomatic and 56.1% mildly symptomatic) were analyzed. In both asymptomatic and mildly symptomatic children, the positive rates of anti-S IgG, anti-SARS-CoV-2 IgG, and NAb were low within 7 days after onset, but they soon reached 100% 14 to <28 days after onset. In symptomatic children, the geometric mean titers (GMTs) of antibodies were all below the positive cutoff during the first 2 weeks from onset and peaked at 28 to <56 days (5.6 for anti-S IgG, 383.6 for anti-SARS-CoV-2 IgG, and 55.0 for NAb, P < .001, respectively). Antibody levels remained detectable up to 3 months after infection. The antibody GMTs during the period 14 to <56 days after symptom onset were highest in children aged 0-4 years. CONCLUSIONS: These results collectively present the humoral immune responses during SARS-CoV-2 infection in children. A further longitudinal study is needed to thoroughly understand the immune system and for effective vaccine development in children during the COVID-19 pandemic. | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press | - |
dc.title | Antibody Responses to SARS-CoV-2 in Children With COVID-19 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/jpids/piac012 | - |
dc.citation.journaltitle | Journal of the Pediatric Infectious Diseases Society | - |
dc.identifier.wosid | 000768377200001 | - |
dc.identifier.scopusid | 2-s2.0-85133100804 | - |
dc.citation.endpage | 273 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 267 | - |
dc.citation.volume | 11 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Choi, Eun Hwa | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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