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Effects of ischemic conditioning on head and neck free flap oxygenation: a randomized controlled trial

DC Field Value Language
dc.contributor.authorMin, Se-Hee-
dc.contributor.authorChoe, Suk Hyung-
dc.contributor.authorKim, Won Shik-
dc.contributor.authorAhn, Soon-Hyun-
dc.contributor.authorCho, Youn Joung-
dc.date.accessioned2022-09-29T03:19:51Z-
dc.date.available2022-09-29T03:19:51Z-
dc.date.created2022-07-21-
dc.date.issued2022-05-
dc.identifier.citationScientific Reports, Vol.12 No.1, p. 8130-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://hdl.handle.net/10371/184752-
dc.description.abstractFlap failure after microvascular reconstructive surgery is a rare but devastating complication caused by reperfusion injury and tissue hypoperfusion. Remote ischemic conditioning (RIC) provides protection against ischemia/reperfusion injury and reduces tissue infarction. We hypothesized that RIC would enhance flap oxygenation and exert organ-protective effects during head and neck free flap reconstructive surgery. Adult patients undergoing free flap transfer surgery for head and neck cancer were randomized to receive either RIC or sham-RIC during surgery. RIC consisted of four cycles of 5-min ischemia and 5-min reperfusion applied to the upper or lower extremity. The primary endpoint, tissue oxygen saturation of the flap, was measured by near-infrared spectroscopy on the first postoperative day. Organ-protective effects of RIC were evaluated with infarct size of rat hearts perfused with plasma dialysate from patients received RIC or sham-RIC. Between April 2018 and July 2019, 50 patients were randomized (each n = 25) and 46 were analyzed in the RIC (n = 23) or sham-RIC (n = 23) groups. Tissue oxygen saturation of the flap was similar between the groups (85 +/- 12% vs 83 +/- 9% in the RIC vs sham-RIC groups; P = 0.471). Myocardial infarct size after treatment of plasma dialysate was significantly reduced in the RIC group (44 +/- 7% to 26 +/- 6%; P = 0.018) compared to the sham-RIC group (42 +/- 6% to 37 +/- 7%; P = 0.388). RIC did not improve tissue oxygenation of the transferred free flap in head and neck cancer reconstructive surgery. However, there was evidence of organ-protective effects of RIC in experimental models. Trial registration: Registry number of ClinicalTrials.gov: NCT03474952.-
dc.language영어-
dc.publisherNature Publishing Group-
dc.titleEffects of ischemic conditioning on head and neck free flap oxygenation: a randomized controlled trial-
dc.typeArticle-
dc.identifier.doi10.1038/s41598-022-12374-3-
dc.citation.journaltitleScientific Reports-
dc.identifier.wosid000815482800086-
dc.identifier.scopusid2-s2.0-85130111375-
dc.citation.number1-
dc.citation.startpage8130-
dc.citation.volume12-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorAhn, Soon-Hyun-
dc.type.docTypeArticle-
dc.description.journalClass1-
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