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Metabolic Syndrome as a Risk Factor of Endometrial Cancer: A Nationwide Population-Based Cohort Study of 2.8 Million Women in South Korea
DC Field | Value | Language |
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dc.contributor.author | Jo, HyunA | - |
dc.contributor.author | Kim, Se Ik | - |
dc.contributor.author | Wang, Wenyu | - |
dc.contributor.author | Seol, Aeran | - |
dc.contributor.author | Han, Youngjin | - |
dc.contributor.author | Kim, Junhwan | - |
dc.contributor.author | Park, In Sil | - |
dc.contributor.author | Lee, Juwon | - |
dc.contributor.author | Yoo, Juhwan | - |
dc.contributor.author | Han, Kyung-Do | - |
dc.contributor.author | Song, Yong Sang | - |
dc.date.accessioned | 2022-10-04T08:28:19Z | - |
dc.date.available | 2022-10-04T08:28:19Z | - |
dc.date.created | 2022-07-12 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | Frontiers in Oncology, Vol.12, p. 872995 | - |
dc.identifier.issn | 2234-943X | - |
dc.identifier.uri | https://hdl.handle.net/10371/185234 | - |
dc.description.abstract | BackgroundA positive relationship was reported between metabolic syndrome and the risk of endometrial cancer. Studies on the relationship between metabolic syndrome and endometrial cancer have been mainly conducted in post-menopausal women. We aimed to investigate the risk of endometrial cancer according to metabolic syndrome and menopausal status using the Korean nationwide population-based cohort. MethodsWe enrolled 2,824,107 adults (endometrial cancer group; N = 5,604 and control group; N= 2,818,503) from the Korean National Health Insurance Service checkup database from January 1 to December 31, 2009. The median follow-up duration was 8.37 years. Metabolic syndrome was diagnosed as having at least three of the following five components: abdominal obesity, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol, raised blood pressure, and hyperglycemia. Multivariate Cox proportional hazard models were used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) to estimate endometrial cancer risk. ResultsThe endometrial cancer risk was higher in the metabolic syndrome group than that in the non-metabolic syndrome group (HR, 1.362; 95% CI, 1.281-1.449). The association between metabolic syndrome and endometrial cancer risk was significant in the premenopausal subgroup (HR, 1.543; 95% CI, 1.39-1.713) and postmenopausal subgroup (HR, 1.306; 95% CI, 1.213-1.407). The incidence of endometrial cancer was more closely related to metabolic syndrome components in the pre-menopausal subgroup than those in the post-menopausal subgroup (for waist circumference, blood pressure, triglycerides and high-density lipoprotein cholesterol, all p for interaction <0.0001 respectively, and for fasting blood glucose, p for interaction 0.0188). The incidence of endometrial cancer positively correlated with the number of metabolic syndrome components (log-rank p <0.0001). ConclusionOur large population-based cohort study in Korean women suggests that metabolic syndrome and its accumulated components may be risk factors for endometrial cancer, particularly in the pre-menopausal women. | - |
dc.language | 영어 | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Metabolic Syndrome as a Risk Factor of Endometrial Cancer: A Nationwide Population-Based Cohort Study of 2.8 Million Women in South Korea | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fonc.2022.872995 | - |
dc.citation.journaltitle | Frontiers in Oncology | - |
dc.identifier.wosid | 000818504200001 | - |
dc.identifier.scopusid | 2-s2.0-85133503207 | - |
dc.citation.startpage | 872995 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Song, Yong Sang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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