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Prevalence and clinical characteristics of primary aldosteronism in a tertiary-care center in Korea
DC Field | Value | Language |
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dc.contributor.author | Yoon, Minjae | - |
dc.contributor.author | Hong, Namki | - |
dc.contributor.author | Ha, Jaehyung | - |
dc.contributor.author | Lee, Chan Joo | - |
dc.contributor.author | Ku, Cheol Ryong | - |
dc.contributor.author | Rhee, Yumie | - |
dc.contributor.author | Park, Sungha | - |
dc.date.accessioned | 2022-10-05T04:22:03Z | - |
dc.date.available | 2022-10-05T04:22:03Z | - |
dc.date.created | 2022-08-23 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | Hypertension Research, Vol.45 No.9, pp.1418-1429 | - |
dc.identifier.issn | 0916-9636 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185447 | - |
dc.description.abstract | Approximately 29% of Korean adults have hypertension; however, the prevalence of primary aldosteronism among the hypertensive population is largely unknown. The aim of our study was to evaluate the prevalence and clinical characteristics of primary aldosteronism in a tertiary-care center in Korea. We retrospectively analyzed 1173 patients with newly diagnosed or preexisting hypertension who were referred to our tertiary-care hospital between January 2013 and December 2018. Patients were screened for primary aldosteronism with the aldosterone-renin ratio and underwent a saline infusion test for diagnostic confirmation. Adrenal computed tomography and adrenal venous sampling were performed for subtype classification for primary aldosteronism. Among the 1173 patients (mean age, 51.8 years; women, 53.2%), 360 (30.7%) had positive screening-test results, of whom 71 (6.1%) were finally diagnosed with primary aldosteronism. Conclusive subtype differentiation was made in 55 patients, of whom 15 (27%) had an aldosterone-producing adenoma, 4 (7%) had unilateral adrenal hyperplasia, and 36 (66%) had bilateral adrenal hyperplasia. Patients with primary aldosteronism had a higher ambulatory blood pressure, left ventricular mass index, and urinary albumin-to-creatinine ratio than those without. Moreover, the primary aldosteronism group had a higher prevalence of left ventricular hypertrophy and albuminuria than the non-primary aldosteronism group. Primary aldosteronism may be more common (6.1%) among Korean patients with hypertension than generally recognized. Primary aldosteronism was associated with a higher degree and prevalence of target organ damage and a higher blood pressure level. Wide application of screening tests for primary aldosteronism may be beneficial in detecting this potentially curable cause of hypertension. | - |
dc.language | 영어 | - |
dc.publisher | Japanese Society of Hypertension | - |
dc.title | Prevalence and clinical characteristics of primary aldosteronism in a tertiary-care center in Korea | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41440-022-00948-7 | - |
dc.citation.journaltitle | Hypertension Research | - |
dc.identifier.wosid | 000808421400005 | - |
dc.identifier.scopusid | 2-s2.0-85131510694 | - |
dc.citation.endpage | 1429 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 1418 | - |
dc.citation.volume | 45 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Yoon, Minjae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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